Lien-Szu. Wu, et.al., Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice., The Journal of biological chemistry, 2012, 287

http://rdf.ncbi.nlm.nih.gov/pubmed/22718760

Lien-Szu. Wu, et.al., Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice., The Journal of biological chemistry, 2012, 287

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• limb grasping_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0001513I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• muscular atrophy_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0002269I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• muscle weakness_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0000747I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• abnormal microglial cell activation_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0010762I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• motor neuron degeneration_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0000938I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• impaired coordination_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0001405I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• astrocytosis_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0003354I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• decreased body weight_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0001262I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• abnormal spinal cord ventral horn morphology_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0005112I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• kyphosis_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0000160I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• abnormal motor neuron morphology_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0000937I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• premature death_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0002083I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks
• weight loss_Mnx1<tm4(cre)Tmj>/Mnx1<+>,Tardbp<tm1.1Ckjs>/Tardbp<tm1.2Cjks>
  http://metadb.riken.jp/0001263I129S1SvC57BL6JMnx1tm4creTmjMnx1Tardbptm11CkjsTardbptm12CjksMnx1Tardbptm11CkjsMnx1tm4creTmjTardbptm12Cjks