Luis E. Gonzalez-Reyes, et.al., Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit., Neuron, 2012, 75

http://rdf.ncbi.nlm.nih.gov/pubmed/22841315

Luis E. Gonzalez-Reyes, et.al., Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit., Neuron, 2012, 75

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Shh<tm1Ahk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5440762

class

http://purl.org/net/cito/citesAsAuthority

• Shh<tm1Ahk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5440762

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• loss of dopaminergic neurons_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0003244I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz
• decreased neuron number_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0008948I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz
• abnormal gait_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0001406I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz
• decreased dopamine level_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0005643I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz
• increased neuron number_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0008947I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz
• no abnormal phenotype detected_Shh<tm1Ahk>/Shh<tm1Ahk>
  http://metadb.riken.jp/0002169B6CgShhtm1AhkShhtm1AhkShhtm1AhkShhtm1Ahk
• increased dopamine level_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0001906I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz
• abnormal synaptic dopamine release_Ret<tm1Kln>/Ret<tm1Kln>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0010149I129S1SvRettm1KlnRettm1KlnSlc6a3tm1creXzSlc6a3Slc6a3tm1creXzSlc6a3Rettm1Kln
• loss of dopaminergic neurons_Ret<tm1Kln>/Ret<tm1Kln>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0003244I129S1SvRettm1KlnRettm1KlnSlc6a3tm1creXzSlc6a3Slc6a3tm1creXzSlc6a3Rettm1Kln
• hypoactivity_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0001402I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz
• hindlimb paralysis_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0000755I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz
• abnormal synaptic dopamine release_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0010149I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz
• hyperactivity_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0001399I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz
• premature death_Shh<tm1Ahk>/Shh<tm1Ahk>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>
  http://metadb.riken.jp/0002083I129S1SvC57BL6Shhtm1AhkShhtm1AhkSlc6a3tm1creXzSlc6a3Shhtm1AhkSlc6a3Slc6a3tm1creXz