Joyoti. Dey, et.al., A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model., Molecular and cellular biology, 2012, 32

http://rdf.ncbi.nlm.nih.gov/pubmed/22869526

Joyoti. Dey, et.al., A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model., Molecular and cellular biology, 2012, 32

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cerebellum morphology_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0000849C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• absent cerebellar foliation_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0000853C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• abnormal cerebellum development_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0000854C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• abnormal cerebellum external granule cell layer morphology_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0000872C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• ectopic Purkinje cell_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0000885C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• weight loss_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0001263C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
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• hypoactivity_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0001402C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• hunched posture_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0001505C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• hydroencephaly_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0001891C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• abnormal radial glial cell morphology_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0003648C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• abnormal cerebellar granule cell morphology_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0004098C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• increased neuronal precursor cell number_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0004980C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• increased neuronal precursor cell number_Ptch1<tm1Bjw>/Ptch1<tm1Bjw>,Tg(Atoh1-cre)1Bfri/0
  http://metadb.riken.jp/0004980I129T2SvEmsC57BL6CBAPtch1tm1BjwPtch1tm1BjwTgAtoh1cre1Bfri0TgAtoh1cre1BfriPtch1tm1Bjw
• head tilt_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0005191C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• lethargy_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0005202C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• abnormal neuronal migration_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0006009C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• increased medulloblastoma incidence_Tg(Neurod2-Smo*A1)199Jols/Tg(Neurod2-Smo*A1)199Jols
  http://metadb.riken.jp/0006283C57BL6TgNeurod2SmoA1199JolsTgNeurod2SmoA1199JolsTgNeurod2SmoA1199JolsTgNeurod2SmoA1199Jols
• increased medulloblastoma incidence_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0006283C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• abnormal neuron proliferation_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0009967C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols
• abnormal head shape_Tg(Neurod2-Smo*A2)#Jols/0
  http://metadb.riken.jp/0011495C57BL6TgNeurod2SmoA2JolsTgNeurod2SmoA2Jols0TgNeurod2SmoA2Jols