Seungmin. Lee, et.al., Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons., Human molecular genetics, 2012, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/22914740

Seungmin. Lee, et.al., Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons., Human molecular genetics, 2012, 21

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Mfn1<tm1.1Arte>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5440838
• Mfn2<tm1.1Arte>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5440839

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased mitochondria number_Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0011629I129S1Sv129X1SvJGtROSA26Sortm1LrsnGtROSA26SorMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11ArteGtROSA26SorGtROSA26Sortm1Lrsn
• weight loss_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0001263I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• premature death_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• abnormal respiratory electron transport chain_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0010955I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• no abnormal phenotype detected_Mfn1<tm1.1Arte>/Mfn1<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0002169I129S1Sv129X1SvJMfn1tm11ArteMfn1tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn1tm11Arte
• decreased dopamine level_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0005643I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• decreased body weight_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• abnormal locomotor activation_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0003313I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• abnormal mitochondrial shape_Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0011633I129S1Sv129X1SvJGtROSA26Sortm1LrsnGtROSA26SorMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11ArteGtROSA26SorGtROSA26Sortm1Lrsn
• increased mitochondria size_Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0011630I129S1Sv129X1SvJGtROSA26Sortm1LrsnGtROSA26SorMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11ArteGtROSA26SorGtROSA26Sortm1Lrsn
• abnormal neuron physiology_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0004811I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• increased serotonin level_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0010069I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• decreased vertical activity_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0002757I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• hypoactivity_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0001402I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• abnormal dopaminergic neuron morphology_Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0003243I129S1Sv129X1SvJGtROSA26Sortm1LrsnGtROSA26SorMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11ArteGtROSA26SorGtROSA26Sortm1Lrsn
• abnormal substantia nigra pars compacta morphology_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0013219I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• abnormal innervation_Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0002184I129S1Sv129X1SvJMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11Arte
• abnormal dorsal striatum morphology_Gt(ROSA)26Sor<tm1Lrsn>/Gt(ROSA)26Sor<+>,Mfn2<tm1.1Arte>/Mfn2<tm1.1Arte>,Slc6a3<tm1(cre)Lrsn>/Slc6a3<+>
  http://metadb.riken.jp/0004102I129S1Sv129X1SvJGtROSA26Sortm1LrsnGtROSA26SorMfn2tm11ArteMfn2tm11ArteSlc6a3tm1creLrsnSlc6a3Slc6a3tm1creLrsnSlc6a3Mfn2tm11ArteGtROSA26SorGtROSA26Sortm1Lrsn

class

http://purl.org/net/cito/citesAsAuthority

• Mfn1<tm1.1Arte>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5440838
• Mfn2<tm1.1Arte>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5440839