Jacqueline C. Mitchell, et.al., Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion., Acta neuropathologica, 2013, 125

http://rdf.ncbi.nlm.nih.gov/pubmed/22961620

Jacqueline C. Mitchell, et.al., Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion., Acta neuropathologica, 2013, 125

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/db/mgi_rdf/MGI:5445385

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal motor capabilities/coordination/movement_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0002066IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• abnormal muscle physiology_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0002106IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• abnormal gait_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0001406IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• muscular atrophy_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0002269IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• abnormal neuromuscular synapse morphology_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0001053IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• abnormal spinal cord morphology_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0000955IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• impaired coordination_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0001405IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• slow postnatal weight gain_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0008489IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• premature death_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0002083IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• microgliosis_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0008918IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• hypoactivity_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0001402IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• tremors_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0000745IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• abnormal neuron morphology_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0002882IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• limb grasping_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0001513IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• impaired muscle relaxation_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0003157IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• abnormal skeletal muscle fiber type ratio_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0009409IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• astrocytosis_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0003354IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• motor neuron degeneration_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0000938IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• microgliosis_Tg(Prnp-FUS)WT3Cshw/0
  http://metadb.riken.jp/0008918IC57BL6CrlCD1ICRTgPrnpFUSWT3Cshw0TgPrnpFUSWT3Cshw
• hindlimb paralysis_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0000755IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw
• impaired skeletal muscle contractility_Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/0002841IC57BL6CrlCD1ICRTgPrnpFUSWT3CshwTgPrnpFUSWT3CshwTgPrnpFUSWT3Cshw

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-FUS)WT3Cshw
  http://metadb.riken.jp/db/mgi_rdf/MGI:5445385