Jin. Jin, et.al., The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling., Nature immunology, 2012, 13

http://rdf.ncbi.nlm.nih.gov/pubmed/23023393

Jin. Jin, et.al., The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling., Nature immunology, 2012, 13

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tbk1<tm1Arte>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5446427

class

http://purl.org/net/cito/citesAsAuthority

• Tbk1<tm1Arte>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5446427

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal B cell differentiation_Nfkb2<Lym1>/Nfkb2<+>
  http://metadb.riken.jp/0002144IBALBcNfkb2Lym1Nfkb2Nfkb2Lym1Nfkb2
• increased anti-double stranded DNA antibody level_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004762I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19
• increased circulating creatinine level_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005553I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19
• abnormal class switch recombination_Map3k14<tm1Rds>/Map3k14<tm1Rds>
  http://metadb.riken.jp/0004816I129SvMap3k14tm1RdsMap3k14tm1RdsMap3k14tm1Rds
• increased IgA level_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002495I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19
• increased urine protein level_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002962I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19
• increased mature B cell number_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008210I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19
• increased IgM level_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002494I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19
• abnormal class switch recombination_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004816I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19
• abnormal B cell physiology_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002459I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19
• increased blood urea nitrogen level_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005565I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19
• abnormal kidney physiology_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002136I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19
• abnormal immunoglobulin level_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Map3k14<tm1Rds>/Map3k14<tm1Rds>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002490I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteMap3k14tm1RdsMap3k14tm1RdsCd19tm1creCgnCd19Map3k14tm1RdsCd19tm1creCgnTbk1tm1ArteCd19
• abnormal B cell differentiation_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Map3k14<tm1Rds>/Map3k14<tm1Rds>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002144I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteMap3k14tm1RdsMap3k14tm1RdsCd19tm1creCgnCd19Map3k14tm1RdsCd19tm1creCgnTbk1tm1ArteCd19
• increased anti-nuclear antigen antibody level_Tbk1<tm1Arte>/Tbk1<tm1Arte>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004794I129SvEv129P2OlaHsdC57BL6Tbk1tm1ArteTbk1tm1ArteCd19tm1creCgnCd19Cd19tm1creCgnTbk1tm1ArteCd19