Jean-Nicolas. Schickel, et.al., Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity., EMBO molecular medicine, 2012, 4

http://rdf.ncbi.nlm.nih.gov/pubmed/23109291

Jean-Nicolas. Schickel, et.al., Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity., EMBO molecular medicine, 2012, 4

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tbc1d10c<tm1.1Psou>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5578033
• Tbc1d10c<tm1.2Psou>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5578034

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased anti-double stranded DNA antibody level_Tbc1d10c<tm1.1Psou>/Tbc1d10c<tm1.2Psou>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0004762I129S2SvPasBALBcC57BL6JTbc1d10ctm11PsouTbc1d10ctm12PsouCd79atm1creRethCd79aTbc1d10ctm11PsouCd79aCd79atm1creRethTbc1d10ctm12Psou
• increased susceptibility to systemic lupus erythematosus_Tbc1d10c<tm1.2Psou>/Tbc1d10c<tm1.2Psou>
  http://metadb.riken.jp/0004801I129S2SvPasC57BL6JTbc1d10ctm12PsouTbc1d10ctm12PsouTbc1d10ctm12Psou
• abnormal response to infection_Tbc1d10c<tm1.2Psou>/Tbc1d10c<tm1.2Psou>
  http://metadb.riken.jp/0005025I129S2SvPasC57BL6JTbc1d10ctm12PsouTbc1d10ctm12PsouTbc1d10ctm12Psou
• increased T cell proliferation_Tbc1d10c<tm1.2Psou>/Tbc1d10c<tm1.2Psou>
  http://metadb.riken.jp/0005348I129S2SvPasC57BL6JTbc1d10ctm12PsouTbc1d10ctm12PsouTbc1d10ctm12Psou
• abnormal B cell physiology_Tbc1d10c<tm1.2Psou>/Tbc1d10c<tm1.2Psou>
  http://metadb.riken.jp/0002459I129S2SvPasC57BL6JTbc1d10ctm12PsouTbc1d10ctm12PsouTbc1d10ctm12Psou
• abnormal B cell physiology_Tbc1d10c<tm1.1Psou>/Tbc1d10c<tm1.2Psou>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0002459I129S2SvPasBALBcC57BL6JTbc1d10ctm11PsouTbc1d10ctm12PsouCd79atm1creRethCd79aTbc1d10ctm11PsouCd79aCd79atm1creRethTbc1d10ctm12Psou
• increased IgM level_Tbc1d10c<tm1.1Psou>/Tbc1d10c<tm1.2Psou>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0002494I129S2SvPasBALBcC57BL6JTbc1d10ctm11PsouTbc1d10ctm12PsouCd79atm1creRethCd79aTbc1d10ctm11PsouCd79aCd79atm1creRethTbc1d10ctm12Psou
• increased anti-double stranded DNA antibody level_Tbc1d10c<tm1.2Psou>/Tbc1d10c<tm1.2Psou>
  http://metadb.riken.jp/0004762I129S2SvPasC57BL6JTbc1d10ctm12PsouTbc1d10ctm12PsouTbc1d10ctm12Psou
• increased susceptibility to systemic lupus erythematosus_Tbc1d10c<tm1.1Psou>/Tbc1d10c<tm1.2Psou>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0004801I129S2SvPasBALBcC57BL6JTbc1d10ctm11PsouTbc1d10ctm12PsouCd79atm1creRethCd79aTbc1d10ctm11PsouCd79aCd79atm1creRethTbc1d10ctm12Psou
• increased IgG level_Tbc1d10c<tm1.2Psou>/Tbc1d10c<tm1.2Psou>
  http://metadb.riken.jp/0002493I129S2SvPasC57BL6JTbc1d10ctm12PsouTbc1d10ctm12PsouTbc1d10ctm12Psou
• increased IgG level_Tbc1d10c<tm1.1Psou>/Tbc1d10c<tm1.2Psou>,Cd79a<tm1(cre)Reth>/Cd79a<+>
  http://metadb.riken.jp/0002493I129S2SvPasBALBcC57BL6JTbc1d10ctm11PsouTbc1d10ctm12PsouCd79atm1creRethCd79aTbc1d10ctm11PsouCd79aCd79atm1creRethTbc1d10ctm12Psou
• abnormal T cell activation_Tbc1d10c<tm1.2Psou>/Tbc1d10c<tm1.2Psou>
  http://metadb.riken.jp/0001828I129S2SvPasC57BL6JTbc1d10ctm12PsouTbc1d10ctm12PsouTbc1d10ctm12Psou

class

http://purl.org/net/cito/citesAsAuthority

• Tbc1d10c<tm1.1Psou>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5578033
• Tbc1d10c<tm1.2Psou>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5578034