Weiming. Ouyang, et.al., Novel Foxo1-dependent transcriptional programs control T(reg) cell function., Nature, 2012, 491

http://rdf.ncbi.nlm.nih.gov/pubmed/23135404

Weiming. Ouyang, et.al., Novel Foxo1-dependent transcriptional programs control T(reg) cell function., Nature, 2012, 491

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Foxo1<tm1.1Moli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5447984
• Gt(ROSA)26Sor<tm1(CAG-FOXO1,GFP)Moli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5447989

class

http://purl.org/net/cito/citesAsAuthority

• Foxo1<tm1.1Moli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5447984
• Gt(ROSA)26Sor<tm1(CAG-FOXO1,GFP)Moli>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5447989

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased regulatory T cell number_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0004973I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• increased interferon-gamma secretion_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008566I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• increased CD8-positive, alpha-beta T cell number_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Ifng<tm1Ts>/Ifng<tm1Ts>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008078I129S1Sv129S6SvEvTac129S7SvEvBrd129X1SvJFoxo1tm1FlvFoxo1tm1FlvIfngtm1TsIfngtm1TsFoxp3tm4YFPicreAyrFoxp3Foxo1tm1FlvIfngtm1TsFoxp3Foxp3tm4YFPicreAyr
• premature death_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0002083I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• increased CD4-positive, alpha beta T cell number_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Ifng<tm1Ts>/Ifng<tm1Ts>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008074I129S1Sv129S6SvEvTac129S7SvEvBrd129X1SvJFoxo1tm1FlvFoxo1tm1FlvIfngtm1TsIfngtm1TsFoxp3tm4YFPicreAyrFoxp3Foxo1tm1FlvIfngtm1TsFoxp3Foxp3tm4YFPicreAyr
• increased T cell proliferation_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0005348I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• enlarged spleen_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0000691I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• increased CD4-positive, alpha beta T cell number_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008074I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• abnormal skin appearance_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0009931I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• abnormal inflammatory response_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0001845I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• paralysis_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0000753I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• hunched posture_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0001505I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• increased CD8-positive, alpha-beta T cell number_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008078I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• increased T cell number_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0005015I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• abnormal regulatory T cell physiology_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0004946I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• enlarged lymph nodes_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0000702I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv
• increased interferon-gamma secretion_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Tg(UBC-cre/ERT2)1Ejb/0
  http://metadb.riken.jp/0008566I129SSvEv129S6SvEvTacC57BL6Foxo1tm1FlvFoxo1tm1FlvTgUBCcreERT21Ejb0Foxo1tm1FlvTgUBCcreERT21Ejb
• abnormal tail morphology_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0002111I129S1Sv129S6SvEvTac129X1SvJFoxo1tm1FlvFoxo1tm1FlvFoxp3tm4YFPicreAyrFoxp3Foxp3tm4YFPicreAyrFoxp3Foxo1tm1Flv