Christine. Longuet, et.al., Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor., Diabetes, 2013, 62

http://rdf.ncbi.nlm.nih.gov/pubmed/23160527

Christine. Longuet, et.al., Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor., Diabetes, 2013, 62

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gcgr<tm2.1Mjch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5566811

class

http://purl.org/net/cito/citesAsAuthority

• Gcgr<tm2.1Mjch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5566811

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pancreatic alpha cell physiology_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003563IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• increased pancreatic alpha cell number_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0009176I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• increased glucagon secretion_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0002710I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• increased bile salt level_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0004789IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• abnormal pancreatic beta cell morphology_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0005217I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• decreased circulating insulin level_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002727IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• improved glucose tolerance_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0005292I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• improved glucose tolerance_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005292IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• increased pancreas weight_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0009108I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• increased bile salt level_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0004789I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• abnormal pancreatic alpha cell morphology_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0005216I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• abnormal pancreatic alpha cell physiology_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0003563I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• hypoglycemia_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000189IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• decreased circulating glucose level_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005560IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• increased circulating glucagon level_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0002712I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• decreased circulating insulin level_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0002727I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• abnormal pancreatic beta cell morphology_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005217IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• increased pancreas weight_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0009108IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• increased insulin sensitivity_Gcgr<tm1Mjch>/Gcgr<tm1Mjch>
  http://metadb.riken.jp/0002891I129C57BL6JSJLGcgrtm1MjchGcgrtm1MjchGcgrtm1Mjch
• increased pancreatic alpha cell number_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0009176IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• increased insulin sensitivity_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002891IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• abnormal glucose homeostasis_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002078IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch
• increased circulating glucagon level_Gcgr<tm2.1Mjch>/Gcgr<tm2.1Mjch>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002712IC57BL6DBASJLGcgrtm21MjchGcgrtm21MjchTgAlbcre21Mgn0TgAlbcre21MgnGcgrtm21Mjch