Janna. Schneppenheim, et.al., The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain., The Journal of experimental medicine, 2013, 210

http://rdf.ncbi.nlm.nih.gov/pubmed/23267015

Janna. Schneppenheim, et.al., The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain., The Journal of experimental medicine, 2013, 210

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sppl2a<tm1Basc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5491887

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased B-1 B cell number_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0004978I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• small Peyer's patches_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008135I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased T cell number_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0005018I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• abnormal B cell physiology_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0002459I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased IgG2b level_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008497I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased marginal zone B cell number_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008182I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased IgG1 level_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008495I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased transitional stage T2 B cell number_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0009926I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased Peyer's patch number_Cd74<tm1Liz>/Cd74<tm1Liz>,Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008133B6129Sppl2atm1BascCd74tm1LizCd74tm1LizCd74tm1LizSppl2atm1BascSppl2atm1BascSppl2atm1BascCd74tm1Liz
• arrested B cell differentiation_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0001802I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased IgG3 level_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008498I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased IgG2a level_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008496I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased B cell number_Cd74<tm1Liz>/Cd74<tm1Liz>
  http://metadb.riken.jp/0005017B6129SCd74tm1LizJCd74tm1LizCd74tm1LizCd74tm1Liz
• decreased B cell number_Cd74<tm1Liz>/Cd74<tm1Liz>,Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0005017B6129Sppl2atm1BascCd74tm1LizCd74tm1LizCd74tm1LizSppl2atm1BascSppl2atm1BascSppl2atm1BascCd74tm1Liz
• decreased B-2 B cell number_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008207I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased Peyer's patch number_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008133I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased IgM level_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0001806I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• small spleen_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0000692I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased follicular B cell number_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008174I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased B cell number_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0005017I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased IgA level_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0001807I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc
• decreased mature B cell number_Sppl2a<tm1Basc>/Sppl2a<tm1Basc>
  http://metadb.riken.jp/0008211I129S1Sv129X1SvJC57BL6NCrlSppl2atm1BascSppl2atm1BascSppl2atm1Basc

class

http://purl.org/net/cito/citesAsAuthority

• Sppl2a<tm1Basc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5491887