Wen-Mei. Yu, et.al., Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation., Cell stem cell, 2013, 12

http://rdf.ncbi.nlm.nih.gov/pubmed/23290137

Wen-Mei. Yu, et.al., Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation., Cell stem cell, 2013, 12

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• pancytopenia_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005152I129S6SvEvTacC57BL6CBASJLPtpmt1tm21CkqPtpmt1tm21CkqTgMx1cre1Cgn0Ptpmt1tm21CkqTgMx1cre1Cgn
• anemia_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001577I129S6SvEvTacC57BL6CBASJLPtpmt1tm21CkqPtpmt1tm21CkqTgMx1cre1Cgn0Ptpmt1tm21CkqTgMx1cre1Cgn
• pancytopenia_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0005152I129S6SvEvTacC57BL6JSJLPtpmt1tm21CkqPtpmt1tm21CkqTgVav1cre1Graf0Ptpmt1tm21CkqTgVav1cre1Graf
• postnatal lethality, complete penetrance_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0011085I129S6SvEvTacC57BL6JSJLPtpmt1tm21CkqPtpmt1tm21CkqTgVav1cre1Graf0Ptpmt1tm21CkqTgVav1cre1Graf
• premature death_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6CBASJLPtpmt1tm21CkqPtpmt1tm21CkqTgMx1cre1Cgn0Ptpmt1tm21CkqTgMx1cre1Cgn
• small thymus_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000706I129S6SvEvTacC57BL6JSJLPtpmt1tm21CkqPtpmt1tm21CkqTgVav1cre1Graf0Ptpmt1tm21CkqTgVav1cre1Graf
• increased hematopoietic stem cell number_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0004809I129S6SvEvTacC57BL6JSJLPtpmt1tm21CkqPtpmt1tm21CkqTgVav1cre1Graf0Ptpmt1tm21CkqTgVav1cre1Graf
• increased hematopoietic stem cell number_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004809I129S6SvEvTacC57BL6CBASJLPtpmt1tm21CkqPtpmt1tm21CkqTgMx1cre1Cgn0Ptpmt1tm21CkqTgMx1cre1Cgn
• small spleen_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000692I129S6SvEvTacC57BL6JSJLPtpmt1tm21CkqPtpmt1tm21CkqTgVav1cre1Graf0Ptpmt1tm21CkqTgVav1cre1Graf
• abnormal hematopoietic stem cell physiology_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0010763I129S6SvEvTacC57BL6CBASJLPtpmt1tm21CkqPtpmt1tm21CkqTgMx1cre1Cgn0Ptpmt1tm21CkqTgMx1cre1Cgn
• impaired hematopoiesis_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0001606I129S6SvEvTacC57BL6JSJLPtpmt1tm21CkqPtpmt1tm21CkqTgVav1cre1Graf0Ptpmt1tm21CkqTgVav1cre1Graf
• decreased bone marrow cell number_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0000333I129S6SvEvTacC57BL6JSJLPtpmt1tm21CkqPtpmt1tm21CkqTgVav1cre1Graf0Ptpmt1tm21CkqTgVav1cre1Graf
• abnormal common lymphocyte progenitor cell morphology_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008249I129S6SvEvTacC57BL6CBASJLPtpmt1tm21CkqPtpmt1tm21CkqTgMx1cre1Cgn0Ptpmt1tm21CkqTgMx1cre1Cgn
• anemia_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Vav1-cre)1Graf/0
  http://metadb.riken.jp/0001577I129S6SvEvTacC57BL6JSJLPtpmt1tm21CkqPtpmt1tm21CkqTgVav1cre1Graf0Ptpmt1tm21CkqTgVav1cre1Graf
• decreased common myeloid progenitor cell number_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008813I129S6SvEvTacC57BL6CBASJLPtpmt1tm21CkqPtpmt1tm21CkqTgMx1cre1Cgn0Ptpmt1tm21CkqTgMx1cre1Cgn
• abnormal aerobic respiration_Ptpmt1<tm2.1Ckq>/Ptpmt1<tm2.1Ckq>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0010957I129P2OlaHsd129S6SvEvTacC57BL6SJLPtpmt1tm21CkqPtpmt1tm21CkqLyz2tm1creIfoLyz2Ptpmt1tm21CkqLyz2tm1creIfoLyz2