J Ross. Chapman, et.al., RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection., Molecular cell, 2013, 49

http://rdf.ncbi.nlm.nih.gov/pubmed/23333305

J Ross. Chapman, et.al., RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection., Molecular cell, 2013, 49

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• preweaning lethality, incomplete penetrance_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0011110I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• abnormal double-strand DNA break repair_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0010948I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• decreased IgG1 level_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0008495I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• decreased IgG level_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0001805I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• decreased IgG2b level_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0008497I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• preweaning lethality, complete penetrance_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0011100I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• increased susceptibility to bacterial infection_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0002412I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• increased cellular sensitivity to ionizing radiation_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>,Trp53bp1<tm1Jc>/Trp53bp1<tm1Jc>
  http://metadb.riken.jp/0004227I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiTrp53bp1tm1JcTrp53bp1tm1JcRif1GtXT0278WtsiTrp53bp1tm1Jc
• preweaning lethality, complete penetrance_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0011100I129P2OlaHsdMF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• embryonic growth retardation_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0003984I129P2OlaHsdMF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• increased cellular sensitivity to ionizing radiation_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0004227I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• decreased IgG3 level_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0008498I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• decreased IgA level_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0001807I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• abnormal class switch recombination_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0004816I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi
• abnormal DNA repair_Trp53bp1<tm1Jc>/Trp53bp1<tm1Jc>
  http://metadb.riken.jp/0008058I129Trp53bp1tm1JcTrp53bp1tm1JcTrp53bp1tm1Jc
• abnormal DNA repair_Rif1<Gt(XT0278)Wtsi>/Rif1<Gt(XT0278)Wtsi>
  http://metadb.riken.jp/0008058I129P2OlaHsdCD1MF1Rif1GtXT0278WtsiRif1GtXT0278WtsiRif1GtXT0278Wtsi