Otoya. Ueda, et.al., Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor., Scientific reports, 2013, 3

http://rdf.ncbi.nlm.nih.gov/pubmed/23378927

Otoya. Ueda, et.al., Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor., Scientific reports, 2013, 3

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(H2-L-IL6)40Csk
  http://metadb.riken.jp/db/mgi_rdf/MGI:5556099
• Il6ra<tm1.1(IL6R)Csk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5556081

class

http://purl.org/net/cito/citesAsAuthority

• Tg(H2-L-IL6)40Csk
  http://metadb.riken.jp/db/mgi_rdf/MGI:5556099
• Il6ra<tm1.1(IL6R)Csk>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5556081

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged lymph nodes_Il6ra<tm1.1(IL6R)Csk>/Il6ra<tm1.1(IL6R)Csk>,Tg(H2-L-IL6)40Csk/0
  http://metadb.riken.jp/0000702I129S6SvEvTacC57BL6Il6ratm11IL6RCskIl6ratm11IL6RCskTgH2LIL640Csk0Il6ratm11IL6RCskTgH2LIL640Csk
• enlarged lymph nodes_Tg(H2-L-IL6)40Csk/0
  http://metadb.riken.jp/0000702IC57BL6TgH2LIL640Csk0TgH2LIL640Csk
• enlarged spleen_Tg(H2-L-IL6)40Csk/0
  http://metadb.riken.jp/0000691IC57BL6TgH2LIL640Csk0TgH2LIL640Csk
• enlarged spleen_Il6ra<tm1.1(IL6R)Csk>/Il6ra<tm1.1(IL6R)Csk>,Tg(H2-L-IL6)40Csk/0
  http://metadb.riken.jp/0000691I129S6SvEvTacC57BL6Il6ratm11IL6RCskIl6ratm11IL6RCskTgH2LIL640Csk0Il6ratm11IL6RCskTgH2LIL640Csk
• increased plasma cell number_Il6ra<tm1.1(IL6R)Csk>/Il6ra<tm1.1(IL6R)Csk>,Tg(H2-L-IL6)40Csk/0
  http://metadb.riken.jp/0008097I129S6SvEvTacC57BL6Il6ratm11IL6RCskIl6ratm11IL6RCskTgH2LIL640Csk0Il6ratm11IL6RCskTgH2LIL640Csk
• increased spleen weight_Il6ra<tm1.1(IL6R)Csk>/Il6ra<tm1.1(IL6R)Csk>,Tg(H2-L-IL6)40Csk/0
  http://metadb.riken.jp/0004952I129S6SvEvTacC57BL6Il6ratm11IL6RCskIl6ratm11IL6RCskTgH2LIL640Csk0Il6ratm11IL6RCskTgH2LIL640Csk
• increased spleen white pulp amount_Il6ra<tm1.1(IL6R)Csk>/Il6ra<tm1.1(IL6R)Csk>,Tg(H2-L-IL6)40Csk/0
  http://metadb.riken.jp/0008478I129S6SvEvTacC57BL6Il6ratm11IL6RCskIl6ratm11IL6RCskTgH2LIL640Csk0Il6ratm11IL6RCskTgH2LIL640Csk
• abnormal circulating serum amyloid protein level_Il6ra<tm1.1(IL6R)Csk>/Il6ra<tm1.1(IL6R)Csk>
  http://metadb.riken.jp/0010214I129S6SvEvTacC57BL6Il6ratm11IL6RCskIl6ratm11IL6RCskIl6ratm11IL6RCsk
• increased spleen weight_Tg(H2-L-IL6)40Csk/0
  http://metadb.riken.jp/0004952IC57BL6TgH2LIL640Csk0TgH2LIL640Csk