Xuezhi. Dai, et.al., A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models., The Journal of clinical investigation, 2013, 123

http://rdf.ncbi.nlm.nih.gov/pubmed/23619366

Xuezhi. Dai, et.al., A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models., The Journal of clinical investigation, 2013, 123

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5516594
• Gt(ROSA)26Sor<tm1(Ptpn22*)Draw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5516595

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased mature B cell number_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0008211I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• vasculitis_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0001864I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased B cell proliferation_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0005154I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• abnormal B cell activation_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008217I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• abnormal T cell differentiation_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0002145I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• expanded mesangial matrix_Gt(ROSA)26Sor<tm1(Ptpn22*)Draw>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0011353I129P2OlaHsdC57BL6GtROSA26Sortm1Ptpn22DrawGtROSA26SorCd19tm1creCgnCd19Cd19GtROSA26SorGtROSA26Sortm1Ptpn22DrawCd19tm1creCgn
• increased germinal center B cell number_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0008177I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• autoimmune response_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0001844I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased spleen germinal center size_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0008483I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased double-positive T cell number_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0005091I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• abnormal lung morphology_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0001175I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased anti-double stranded DNA antibody level_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0004762I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased B cell number_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0005014I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• abnormal B cell morphology_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0004939I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased T cell proliferation_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0005348I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• spleen hyperplasia_Gt(ROSA)26Sor<tm1(Ptpn22*)Draw>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0000693I129P2OlaHsdC57BL6GtROSA26Sortm1Ptpn22DrawGtROSA26SorCd19tm1creCgnCd19Cd19GtROSA26SorGtROSA26Sortm1Ptpn22DrawCd19tm1creCgn
• increased T cell proliferation_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0005348I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• spleen hyperplasia_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0000693I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• thymus hyperplasia_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0000708I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• abnormal T cell morphology_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008037I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• enlarged spleen_Gt(ROSA)26Sor<tm1(Ptpn22*)Draw>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6GtROSA26Sortm1Ptpn22DrawGtROSA26SorCd19tm1creCgnCd19Cd19GtROSA26SorGtROSA26Sortm1Ptpn22DrawCd19tm1creCgn
• increased transitional stage T1 B cell number_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0009922I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased IgM level_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0002494I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• decreased mature B cell number_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008211I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased IgG1 level_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008499I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased IgG1 level_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0008499I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased IgE level_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0002497I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased spleen germinal center size_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008483I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• abnormal B cell morphology_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0004939I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• abnormal thymus morphology_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0000703I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased B cell number_Gt(ROSA)26Sor<tm1(Ptpn22*)Draw>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005014I129P2OlaHsdC57BL6GtROSA26Sortm1Ptpn22DrawGtROSA26SorCd19tm1creCgnCd19Cd19GtROSA26SorGtROSA26Sortm1Ptpn22DrawCd19tm1creCgn
• decreased B cell apoptosis_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0008783I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• abnormal T cell number_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0006387I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• abnormal B cell differentiation_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0002144I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• thymus hyperplasia_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0000708I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased interleukin-2 secretion_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0008687I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased effector memory CD4-positive, alpha-beta T cell number_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0010844I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased germinal center B cell number_Gt(ROSA)26Sor<tm1(Ptpn22*)Draw>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008177I129P2OlaHsdC57BL6GtROSA26Sortm1Ptpn22DrawGtROSA26SorCd19tm1creCgnCd19Cd19GtROSA26SorGtROSA26Sortm1Ptpn22DrawCd19tm1creCgn
• enlarged spleen_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0000691I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• abnormal T cell physiology_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0002444I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• abnormal B cell physiology_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0002459I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• abnormal B cell physiology_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0002459I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• abnormal salivary gland morphology_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0000613I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased transitional stage T1 B cell number_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0009922I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased interleukin-2 secretion_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008687I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• abnormal T cell morphology_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0008037I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased regulatory T cell number_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0004973I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased inflammatory response_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0001846I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• decreased B cell apoptosis_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008783I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased autoantibody level_Gt(ROSA)26Sor<tm1(Ptpn22*)Draw>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0003725I129P2OlaHsdC57BL6GtROSA26Sortm1Ptpn22DrawGtROSA26SorCd19tm1creCgnCd19Cd19GtROSA26SorGtROSA26Sortm1Ptpn22DrawCd19tm1creCgn
• spleen hyperplasia_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0000693I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased anti-double stranded DNA antibody level_Gt(ROSA)26Sor<tm1(Ptpn22*)Draw>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004762I129P2OlaHsdC57BL6GtROSA26Sortm1Ptpn22DrawGtROSA26SorCd19tm1creCgnCd19Cd19GtROSA26SorGtROSA26Sortm1Ptpn22DrawCd19tm1creCgn
• abnormal B cell differentiation_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0002144I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• decreased follicular B cell number_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0008174I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• abnormal thymus morphology_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0000703I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased germinal center B cell number_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008177I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased regulatory T cell number_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0004973I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• autoimmune response_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0001844I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• enlarged spleen_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0000691I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased B cell number_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0005014I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• premature death_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0002083I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• decreased follicular B cell number_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008174I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased effector memory CD8-positive, alpha-beta T cell number_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0010850I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• abnormal B cell number_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0002458I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased B cell proliferation_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0005154I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased double-positive T cell number_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0005091I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased IgG3 level_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008502I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• glomerulonephritis_Gt(ROSA)26Sor<tm1(Ptpn22*)Draw>/Gt(ROSA)26Sor<+>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002743I129P2OlaHsdC57BL6GtROSA26Sortm1Ptpn22DrawGtROSA26SorCd19tm1creCgnCd19Cd19GtROSA26SorGtROSA26Sortm1Ptpn22DrawCd19tm1creCgn
• glomerulonephritis_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0002743I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• abnormal T cell physiology_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0002444I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased physiological sensitivity to xenobiotic_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0008873I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased anti-insulin autoantibody level_Ptpn22<tm1.1Draw>/Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/0002869I129C57BL6Ptpn22tm11DrawPtpn22tm11DrawPtpn22tm11Draw
• increased CD4-positive, alpha-beta memory T cell number_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0010835I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22
• increased anti-double stranded DNA antibody level_Ptpn22<tm1.1Draw>/Ptpn22<+>
  http://metadb.riken.jp/0004762I129C57BL6Ptpn22tm11DrawPtpn22Ptpn22tm11DrawPtpn22

class

http://purl.org/net/cito/citesAsAuthority

• Ptpn22<tm1.1Draw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5516594
• Gt(ROSA)26Sor<tm1(Ptpn22*)Draw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5516595