Oleg. Timofeev, et.al., p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo., Cell reports, 2013, 3

http://rdf.ncbi.nlm.nih.gov/pubmed/23665223

Oleg. Timofeev, et.al., p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo., Cell reports, 2013, 3

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Trp53<tm1Thst>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5518935
• Trp53<tm1.1Thst>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5518934

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cell physiology_Trp53<tm1Thst>/Trp53<tm1Thst>
  http://metadb.riken.jp/0005621I129S1Sv129X1SvJTrp53tm1ThstTrp53tm1ThstTrp53tm1Thst
• increased teratoma incidence_Trp53<tm1Thst>/Trp53<tm1Thst>
  http://metadb.riken.jp/0002627I129S1Sv129X1SvJTrp53tm1ThstTrp53tm1ThstTrp53tm1Thst
• premature death_Trp53<tm1Thst>/Trp53<tm1Thst>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJTrp53tm1ThstTrp53tm1ThstTrp53tm1Thst
• oxidative stress_Trp53<tm1Thst>/Trp53<tm1Thst>
  http://metadb.riken.jp/0003674I129S1Sv129X1SvJTrp53tm1ThstTrp53tm1ThstTrp53tm1Thst
• increased lymphoma incidence_Trp53<tm1.1Thst>/Trp53<+>,Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0012431I129S1Sv129S4SvJae129X1SvJC57BLSJLTrp53tm11ThstTrp53TgIghMyc22Bri0Trp53tm11ThstTgIghMyc22BriTrp53
• spleen hyperplasia_Trp53<tm1.1Thst>/Trp53<+>
  http://metadb.riken.jp/0000693I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53Trp53tm11ThstTrp53
• decreased thymocyte apoptosis_Trp53<tm1Thst>/Trp53<tm1Thst>
  http://metadb.riken.jp/0009542I129S1Sv129X1SvJTrp53tm1ThstTrp53tm1ThstTrp53tm1Thst
• premature death_Trp53<tm1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJTrp53tm1ThstTrp53tm11ThstTrp53tm1ThstTrp53tm11Thst
• decreased thymocyte apoptosis_Trp53<tm1.1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0009542I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53tm11ThstTrp53tm11Thst
• increased carcinoma incidence_Trp53<tm1Thst>/Trp53<tm1Thst>
  http://metadb.riken.jp/0002038I129S1Sv129X1SvJTrp53tm1ThstTrp53tm1ThstTrp53tm1Thst
• increased carcinoma incidence_Trp53<tm1.1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0002038I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53tm11ThstTrp53tm11Thst
• increased tumor incidence_Trp53<tm1.1Thst>/Trp53<+>
  http://metadb.riken.jp/0002020I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53Trp53tm11ThstTrp53
• spleen hyperplasia_Trp53<tm1Thst>/Trp53<+>
  http://metadb.riken.jp/0000693I129S1Sv129X1SvJTrp53tm1ThstTrp53Trp53tm1ThstTrp53
• spleen hyperplasia_Trp53<tm1.1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0000693I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53tm11ThstTrp53tm11Thst
• increased tumor incidence_Trp53<tm1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0002020I129S1Sv129S4SvJae129X1SvJTrp53tm1ThstTrp53tm11ThstTrp53tm1ThstTrp53tm11Thst
• decreased cellular sensitivity to gamma-irradiation_Trp53<tm1Thst>/Trp53<tm1Thst>
  http://metadb.riken.jp/0003207I129S1Sv129X1SvJTrp53tm1ThstTrp53tm1ThstTrp53tm1Thst
• increased hemangiosarcoma incidence_Trp53<tm1.1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0003667I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53tm11ThstTrp53tm11Thst
• increased T cell derived lymphoma incidence_Trp53<tm1Thst>/Trp53<tm1Thst>
  http://metadb.riken.jp/0002024I129S1Sv129X1SvJTrp53tm1ThstTrp53tm1ThstTrp53tm1Thst
• increased tumor incidence_Trp53<tm1.1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0002020I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53tm11ThstTrp53tm11Thst
• increased T cell derived lymphoma incidence_Trp53<tm1.1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0002024I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53tm11ThstTrp53tm11Thst
• increased leiomyosarcoma incidence_Trp53<tm1.1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0002035I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53tm11ThstTrp53tm11Thst
• premature death_Trp53<tm1.1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53tm11ThstTrp53tm11Thst
• premature death_Trp53<tm1Thst>/Trp53<+>,Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BLSJLTrp53tm1ThstTrp53TgIghMyc22Bri0TgIghMyc22BriTrp53Trp53tm1Thst
• spleen hyperplasia_Trp53<tm1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0000693I129S1Sv129S4SvJae129X1SvJTrp53tm1ThstTrp53tm11ThstTrp53tm1ThstTrp53tm11Thst
• increased lymphoma incidence_Trp53<tm1Thst>/Trp53<+>,Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0012431I129S1Sv129X1SvJC57BLSJLTrp53tm1ThstTrp53TgIghMyc22Bri0TgIghMyc22BriTrp53Trp53tm1Thst
• premature death_Trp53<tm1.1Thst>/Trp53<+>
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53Trp53tm11ThstTrp53
• abnormal cell physiology_Trp53<tm1.1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0005621I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53tm11ThstTrp53tm11Thst
• premature death_Trp53<tm1.1Thst>/Trp53<+>,Tg(IghMyc)22Bri/0
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJC57BLSJLTrp53tm11ThstTrp53TgIghMyc22Bri0Trp53tm11ThstTgIghMyc22BriTrp53
• decreased cellular sensitivity to gamma-irradiation_Trp53<tm1.1Thst>/Trp53<tm1.1Thst>
  http://metadb.riken.jp/0003207I129S1Sv129S4SvJae129X1SvJTrp53tm11ThstTrp53tm11ThstTrp53tm11Thst
• increased tumor incidence_Trp53<tm1Thst>/Trp53<+>
  http://metadb.riken.jp/0002020I129S1Sv129X1SvJTrp53tm1ThstTrp53Trp53tm1ThstTrp53
• increased tumor incidence_Trp53<tm1Thst>/Trp53<tm1Thst>
  http://metadb.riken.jp/0002020I129S1Sv129X1SvJTrp53tm1ThstTrp53tm1ThstTrp53tm1Thst
• premature death_Trp53<tm1Thst>/Trp53<+>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJTrp53tm1ThstTrp53Trp53tm1ThstTrp53

class

http://purl.org/net/cito/citesAsAuthority

• Trp53<tm1Thst>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5518935
• Trp53<tm1.1Thst>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5518934