Marc A. Kerenyi, et.al., Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation., eLife, 2013, 2

http://rdf.ncbi.nlm.nih.gov/pubmed/23795291

Marc A. Kerenyi, et.al., Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation., eLife, 2013, 2

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Kdm1a<tm1.1Sho>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5514399

class

http://purl.org/net/cito/citesAsAuthority

• Kdm1a<tm1.1Sho>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5514399

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal definitive hematopoiesis_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0002123I129C57BL6CBACaKdm1atm11ShoKdm1atm11ShoTgMx1cre1CgnTgMx1cre1CgnKdm1atm11Sho
• abnormal common myeloid progenitor cell morphology_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0006410I129C57BL6CBACaKdm1atm11ShoKdm1atm11ShoTgMx1cre1CgnTgMx1cre1CgnKdm1atm11Sho
• decreased hematopoietic stem cell number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0004810I129C57BL6CBACaKdm1atm11ShoKdm1atm11ShoTgMx1cre1CgnTgMx1cre1CgnKdm1atm11Sho
• decreased hematopoietic stem cell number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0004810I129C57BL6C57BL10CBACaKdm1atm11ShoKdm1atm11ShoTgVav1icreA2Kio0TgVav1icreA2KioKdm1atm11Sho
• decreased common myeloid progenitor cell number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008813I129C57BL6CBACaKdm1atm11ShoKdm1atm11ShoTgMx1cre1CgnTgMx1cre1CgnKdm1atm11Sho
• decreased neutrophil cell number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000222I129C57BL6CBACaKdm1atm11ShoKdm1atm11ShoTgMx1cre1CgnTgMx1cre1CgnKdm1atm11Sho
• decreased body size_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0001265I129C57BL6C57BL10CBACaKdm1atm11ShoKdm1atm11ShoTgVav1icreA2Kio0TgVav1icreA2KioKdm1atm11Sho
• reticulocytopenia_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Epor<tm1(EGFP/cre)Uk>/Epor<+>
  http://metadb.riken.jp/0008941I129BALBcJKdm1atm11ShoKdm1atm11ShoEportm1EGFPcreUkEporKdm1atm11ShoEporEportm1EGFPcreUk
• postnatal lethality, incomplete penetrance_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0011086I129C57BL6C57BL10CBACaKdm1atm11ShoKdm1atm11ShoTgVav1icreA2Kio0TgVav1icreA2KioKdm1atm11Sho
• abnormal liver morphology_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Epor<tm1(EGFP/cre)Uk>/Epor<+>
  http://metadb.riken.jp/0000598I129BALBcJKdm1atm11ShoKdm1atm11ShoEportm1EGFPcreUkEporKdm1atm11ShoEporEportm1EGFPcreUk
• abnormal erythropoiesis_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Epor<tm1(EGFP/cre)Uk>/Epor<+>
  http://metadb.riken.jp/0000245I129BALBcJKdm1atm11ShoKdm1atm11ShoEportm1EGFPcreUkEporKdm1atm11ShoEporEportm1EGFPcreUk
• decreased erythrocyte cell number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0002875I129C57BL6C57BL10CBACaKdm1atm11ShoKdm1atm11ShoTgVav1icreA2Kio0TgVav1icreA2KioKdm1atm11Sho
• pale liver_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Epor<tm1(EGFP/cre)Uk>/Epor<+>
  http://metadb.riken.jp/0000603I129BALBcJKdm1atm11ShoKdm1atm11ShoEportm1EGFPcreUkEporKdm1atm11ShoEporEportm1EGFPcreUk
• decreased granulocyte number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000334I129C57BL6CBACaKdm1atm11ShoKdm1atm11ShoTgMx1cre1CgnTgMx1cre1CgnKdm1atm11Sho
• decreased leukocyte cell number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0000221I129C57BL6C57BL10CBACaKdm1atm11ShoKdm1atm11ShoTgVav1icreA2Kio0TgVav1icreA2KioKdm1atm11Sho
• decreased embryo size_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Epor<tm1(EGFP/cre)Uk>/Epor<+>
  http://metadb.riken.jp/0001698I129BALBcJKdm1atm11ShoKdm1atm11ShoEportm1EGFPcreUkEporKdm1atm11ShoEporEportm1EGFPcreUk
• decreased common myeloid progenitor cell number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0008813I129C57BL6C57BL10CBACaKdm1atm11ShoKdm1atm11ShoTgVav1icreA2Kio0TgVav1icreA2KioKdm1atm11Sho
• pancytopenia_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0005152I129C57BL6CBACaKdm1atm11ShoKdm1atm11ShoTgMx1cre1CgnTgMx1cre1CgnKdm1atm11Sho
• abnormal induced morbidity/mortality_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0001657I129C57BL6CBACaKdm1atm11ShoKdm1atm11ShoTgMx1cre1CgnTgMx1cre1CgnKdm1atm11Sho
• abnormal definitive hematopoiesis_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0002123I129C57BL6C57BL10CBACaKdm1atm11ShoKdm1atm11ShoTgVav1icreA2Kio0TgVav1icreA2KioKdm1atm11Sho
• decreased fetal derived definitive erythrocyte cell number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Epor<tm1(EGFP/cre)Uk>/Epor<+>
  http://metadb.riken.jp/0011243I129BALBcJKdm1atm11ShoKdm1atm11ShoEportm1EGFPcreUkEporKdm1atm11ShoEporEportm1EGFPcreUk
• thrombocytopenia_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0003179I129C57BL6C57BL10CBACaKdm1atm11ShoKdm1atm11ShoTgVav1icreA2Kio0TgVav1icreA2KioKdm1atm11Sho
• increased hematopoietic stem cell number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0004809I129C57BL6CBACaKdm1atm11ShoKdm1atm11ShoTgMx1cre1CgnTgMx1cre1CgnKdm1atm11Sho
• decreased bone marrow cell number_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Tg(Vav1-icre)A2Kio/0
  http://metadb.riken.jp/0000333I129C57BL6C57BL10CBACaKdm1atm11ShoKdm1atm11ShoTgVav1icreA2Kio0TgVav1icreA2KioKdm1atm11Sho
• abnormal proerythroblast morphology_Kdm1a<tm1.1Sho>/Kdm1a<tm1.1Sho>,Epor<tm1(EGFP/cre)Uk>/Epor<+>
  http://metadb.riken.jp/0002416I129BALBcJKdm1atm11ShoKdm1atm11ShoEportm1EGFPcreUkEporKdm1atm11ShoEporEportm1EGFPcreUk