Lingjun. Meng, et.al., Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

http://rdf.ncbi.nlm.nih.gov/pubmed/23798389

Lingjun. Meng, et.al., Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gnl3<tm2.1Rylt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5523416
• Gnl3<tm2.2Rylt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5523418

class

http://purl.org/net/cito/citesAsAuthority

• Gnl3<tm2.1Rylt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5523416
• Gnl3<tm2.2Rylt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5523418

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased tegmentum size_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0006102I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• abnormal embryonic neuroepithelium morphology_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004261I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• neonatal lethality, complete penetrance_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011087I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• decreased fibroblast proliferation_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Trp53<tm1Tyj>/Trp53<tm1Tyj>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0011704I129129S2SvPasC57BL6CBAGnl3tm21RyltGnl3tm21RyltTrp53tm1TyjTrp53tm1TyjTgCAGcreEsr15Amc0Trp53tm1TyjTgCAGcreEsr15AmcGnl3tm21Rylt
• abnormal cell death_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Trp53<tm1Tyj>/Trp53<tm1Tyj>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0000313I129129S2SvPasC57BL6CBAGnl3tm21RyltGnl3tm21RyltTrp53tm1TyjTrp53tm1TyjTgCAGcreEsr15Amc0Trp53tm1TyjTgCAGcreEsr15AmcGnl3tm21Rylt
• abnormal diencephalon morphology_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000830I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• abnormal cerebellum development_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000854I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• embryonic lethality before implantation, complete penetrance_Gnl3<tm2.2Rylt>/Gnl3<tm2.2Rylt>
  http://metadb.riken.jp/0011094I129FVBNGnl3tm22RyltGnl3tm22RyltGnl3tm22Rylt
• respiratory failure_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001953I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• decreased fibroblast proliferation_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0011704I129129S2SvPasC57BL6CBAGnl3tm21RyltGnl3tm21RyltTgCAGcreEsr15Amc0TgCAGcreEsr15AmcGnl3tm21Rylt
• abnormal tectum morphology_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0006104I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• abnormal neuronal stem cell morphology_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0012203I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• abnormal cell physiology_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0005621I129129S2SvPasC57BL6CBAGnl3tm21RyltGnl3tm21RyltTgCAGcreEsr15Amc0TgCAGcreEsr15AmcGnl3tm21Rylt
• abnormal cell physiology_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Trp53<tm1Tyj>/Trp53<tm1Tyj>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0005621I129129S2SvPasC57BL6CBAGnl3tm21RyltGnl3tm21RyltTrp53tm1TyjTrp53tm1TyjTgCAGcreEsr15Amc0Trp53tm1TyjTgCAGcreEsr15AmcGnl3tm21Rylt
• abnormal telencephalon morphology_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000787I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• decreased spinal cord size_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000956I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• abnormal brain morphology_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002152I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt
• abnormal embryonic/fetal subventricular zone morphology_Gnl3<tm2.1Rylt>/Gnl3<tm2.1Rylt>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004274I129C57BL6CBAGnl3tm21RyltGnl3tm21RyltTgNescre1Kln0TgNescre1KlnGnl3tm21Rylt