Su Jung. Song, et.al., The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation., Cell stem cell, 2013, 13

http://rdf.ncbi.nlm.nih.gov/pubmed/23827711

Su Jung. Song, et.al., The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation., Cell stem cell, 2013, 13

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm1(CAG-Mir22)Ppp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5527244

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased leukocyte cell number_Col1a1<tm1(CAG-Mir22)Ppp>/Col1a1<tm1(CAG-Mir22)Ppp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000221NSCol1a1tm1CAGMir22PppCol1a1tm1CAGMir22PppTgMx1cre1Cgn0Col1a1tm1CAGMir22PppTgMx1cre1Cgn
• abnormal hematopoietic system morphology/development_Col1a1<tm1(CAG-Mir22)Ppp>/Col1a1<tm1(CAG-Mir22)Ppp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002396NSCol1a1tm1CAGMir22PppCol1a1tm1CAGMir22PppTgMx1cre1Cgn0Col1a1tm1CAGMir22PppTgMx1cre1Cgn
• increased leukemia incidence_Col1a1<tm1(CAG-Mir22)Ppp>/Col1a1<tm1(CAG-Mir22)Ppp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002026NSCol1a1tm1CAGMir22PppCol1a1tm1CAGMir22PppTgMx1cre1Cgn0Col1a1tm1CAGMir22PppTgMx1cre1Cgn
• abnormal erythropoiesis_Col1a1<tm1(CAG-Mir22)Ppp>/Col1a1<tm1(CAG-Mir22)Ppp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000245NSCol1a1tm1CAGMir22PppCol1a1tm1CAGMir22PppTgMx1cre1Cgn0Col1a1tm1CAGMir22PppTgMx1cre1Cgn
• increased hematopoietic stem cell number_Col1a1<tm1(CAG-Mir22)Ppp>/Col1a1<tm1(CAG-Mir22)Ppp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004809NSCol1a1tm1CAGMir22PppCol1a1tm1CAGMir22PppTgMx1cre1Cgn0Col1a1tm1CAGMir22PppTgMx1cre1Cgn
• increased myeloid dendritic cell number_Col1a1<tm1(CAG-Mir22)Ppp>/Col1a1<tm1(CAG-Mir22)Ppp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008121NSCol1a1tm1CAGMir22PppCol1a1tm1CAGMir22PppTgMx1cre1Cgn0Col1a1tm1CAGMir22PppTgMx1cre1Cgn
• anemia_Col1a1<tm1(CAG-Mir22)Ppp>/Col1a1<tm1(CAG-Mir22)Ppp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001577NSCol1a1tm1CAGMir22PppCol1a1tm1CAGMir22PppTgMx1cre1Cgn0Col1a1tm1CAGMir22PppTgMx1cre1Cgn
• increased T cell derived lymphoma incidence_Col1a1<tm1(CAG-Mir22)Ppp>/Col1a1<tm1(CAG-Mir22)Ppp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002024NSCol1a1tm1CAGMir22PppCol1a1tm1CAGMir22PppTgMx1cre1Cgn0Col1a1tm1CAGMir22PppTgMx1cre1Cgn
• enlarged spleen_Col1a1<tm1(CAG-Mir22)Ppp>/Col1a1<tm1(CAG-Mir22)Ppp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691NSCol1a1tm1CAGMir22PppCol1a1tm1CAGMir22PppTgMx1cre1Cgn0Col1a1tm1CAGMir22PppTgMx1cre1Cgn

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm1(CAG-Mir22)Ppp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5527244