Valerie S. Salazar, et.al., Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype., Journal of cell science, 2013, 126

http://rdf.ncbi.nlm.nih.gov/pubmed/24006258

Valerie S. Salazar, et.al., Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype., Journal of cell science, 2013, 126

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• delayed bone ossification_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000060I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• decreased bone mineral density_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000063I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• malocclusion_Smad4<tm2.1Cxd>/Smad4<+>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000120I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4TgSp7tTAtetOEGFPcre1Amc0Smad4TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• malocclusion_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000120I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• abnormal trabecular bone morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000130I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• decreased compact bone thickness_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000135I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
他23件を見る
• abnormal tibia morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000558I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• decreased body size_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0001265I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• premature death_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• abnormal tooth morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002100I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• abnormal enamel morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002576I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• short tibia_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002764I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• short tibia_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002764ICD1TgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1Amc
• increased compact bone thickness_Smad4<tm2.1Cxd>/Smad4<+>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0004148I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4TgSp7tTAtetOEGFPcre1Amc0Smad4TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• increased compact bone thickness_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0004148ICD1TgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1Amc
• abnormal long bone diaphysis morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0004214I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• clavicle hypoplasia_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0004337I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• rib fractures_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0004675I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• small thoracic cavity_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0004734I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• decreased osteoclast cell number_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0004985I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• abnormal osteoblast physiology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0005006I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• abnormal incisor morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0005358I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• decreased diameter of tibia_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0008156I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• decreased diameter of tibia_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0008156ICD1TgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1Amc
• abnormal osteocyte morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0008753I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• decreased trabecular bone volume_Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0010879ICD1TgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1Amc
• abnormal compact bone lamellar structure_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0010970I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• postnatal lethality, incomplete penetrance_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0011086I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd
• abnormal bone collagen fibril morphology_Smad4<tm2.1Cxd>/Smad4<tm2.1Cxd>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0011642I129S6SvEvTacC57BL6JCD1Smad4tm21CxdSmad4tm21CxdTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcSmad4tm21Cxd