Elizabeth E. Gerber, et.al., Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma., Nature, 2013, 503

http://rdf.ncbi.nlm.nih.gov/pubmed/24107997

Elizabeth E. Gerber, et.al., Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma., Nature, 2013, 503

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Fbn1<tm2.1Hcd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5558867
• Fbn1<tm3.1Hcd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5558868

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• epidermal hyperplasia_Fbn1<tm2.1Hcd>/Fbn1<+>,Itgb3<tm1Hyn>/Itgb3<+>
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• epidermal hyperplasia_Fbn1<tm3.1Hcd>/Fbn1<+>,Itgb3<tm1Hyn>/Itgb3<+>
  http://metadb.riken.jp/0001222I129S129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Itgb3tm1HynItgb3Itgb3tm1HynFbn1Fbn1tm31HcdItgb3
• abnormal dermal layer morphology_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0001243I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• abnormal dermal layer morphology_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0001243I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• thick dermal layer_Fbn1<tm2.1Hcd>/Fbn1<+>,Itgb3<tm1Hyn>/Itgb3<+>
  http://metadb.riken.jp/0001245I129S129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Itgb3tm1HynItgb3Itgb3tm1HynFbn1Fbn1tm21HcdItgb3
• thick dermal layer_Fbn1<tm3.1Hcd>/Fbn1<+>,Itgb3<tm1Hyn>/Itgb3<+>
  http://metadb.riken.jp/0001245I129S129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Itgb3tm1HynItgb3Itgb3tm1HynFbn1Fbn1tm31HcdItgb3
他26件を見る
• abnormal T-helper 1 cell morphology_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0002433I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• abnormal T-helper 1 cell morphology_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0002433I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• abnormal skin turgor_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0003652I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• abnormal skin turgor_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0003652I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• increased autoantibody level_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0003725I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• increased autoantibody level_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0003725I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• increased anti-nuclear antigen antibody level_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0004794I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• increased anti-nuclear antigen antibody level_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0004794I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• increased B cell number_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0005014I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• increased B cell number_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0005014I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• increased plasma cell number_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008097I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• increased plasma cell number_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008097I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• abnormal cutaneous collagen fibril morphology_Fbn1<tm2.1Hcd>/Fbn1<+>,Itgb3<tm1Hyn>/Itgb3<+>
  http://metadb.riken.jp/0008438I129S129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Itgb3tm1HynItgb3Itgb3tm1HynFbn1Fbn1tm21HcdItgb3
• abnormal cutaneous collagen fibril morphology_Fbn1<tm3.1Hcd>/Fbn1<+>,Itgb3<tm1Hyn>/Itgb3<+>
  http://metadb.riken.jp/0008438I129S129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Itgb3tm1HynItgb3Itgb3tm1HynFbn1Fbn1tm31HcdItgb3
• abnormal cutaneous collagen fibril morphology_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008438I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• abnormal cutaneous collagen fibril morphology_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008438I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• abnormal interleukin secretion_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008568I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• abnormal interleukin secretion_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008568I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• increased interleukin-13 secretion_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008672I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• increased interleukin-13 secretion_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008672I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• increased interleukin-9 secretion_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008711I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• increased interleukin-9 secretion_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008711I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• decreased subcutaneous adipose tissue amount_Fbn1<tm2.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008844I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1Fbn1tm21HcdFbn1
• decreased subcutaneous adipose tissue amount_Fbn1<tm3.1Hcd>/Fbn1<+>
  http://metadb.riken.jp/0008844I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1Fbn1tm31HcdFbn1
• skin fibrosis_Fbn1<tm3.1Hcd>/Fbn1<tm3.1Hcd>
  http://metadb.riken.jp/0009932I129S1Sv129X1SvJC57BL6JFVBNFbn1tm31HcdFbn1tm31HcdFbn1tm31Hcd
• embryonic lethality, complete penetrance_Fbn1<tm2.1Hcd>/Fbn1<tm2.1Hcd>
  http://metadb.riken.jp/0011092I129S1Sv129X1SvJC57BL6JFVBNFbn1tm21HcdFbn1tm21HcdFbn1tm21Hcd

class

http://purl.org/net/cito/citesAsAuthority

• Fbn1<tm2.1Hcd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5558867
• Fbn1<tm3.1Hcd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5558868