Hyung-seung. Jin, et.al., Itch expression by Treg cells controls Th2 inflammatory responses., The Journal of clinical investigation, 2013, 123

http://rdf.ncbi.nlm.nih.gov/pubmed/24135136

Hyung-seung. Jin, et.al., Itch expression by Treg cells controls Th2 inflammatory responses., The Journal of clinical investigation, 2013, 123

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Itch<tm1.1Alta>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5563090

class

http://purl.org/net/cito/citesAsAuthority

• Itch<tm1.1Alta>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5563090

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased leukocyte cell number_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0000218I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• enlarged spleen_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0000691I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• enlarged lymph nodes_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0000702I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• dermatitis_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0001194I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• skin lesions_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0001212I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• weight loss_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0001263I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
他25件を見る
• increased inflammatory response_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0001846I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased inflammatory response_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Gt(ROSA)26Sor<tm1Hjf>/Gt(ROSA)26Sor<+>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0001846I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaGtROSA26Sortm1HjfGtROSA26SorFoxp3tm4YFPicreAyrFoxp3GtROSA26SorFoxp3tm4YFPicreAyrFoxp3Itchtm11AltaGtROSA26Sortm1Hjf
• lung inflammation_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0001861I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• premature death_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• abnormal lymph organ size_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0002221I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• abnormal lymphopoiesis_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0002401I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• abnormal immunoglobulin level_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0002490I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased IgA level_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0002495I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased IgE level_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0002497I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• abnormal regulatory T cell physiology_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0004946I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased regulatory T cell number_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0004973I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased eosinophil cell number_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0005011I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• abnormal T-helper 2 physiology_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0005466I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased CD4-positive, alpha beta T cell number_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008074I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• decreased CD4-positive, alpha beta T cell number_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008075I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased CD8-positive, alpha-beta T cell number_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008078I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• abnormal T-helper 2 cell differentiation_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008092I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased IgG1 level_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008499I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• abnormal interleukin secretion_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008568I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased interleukin-10 secretion_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008660I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased interleukin-13 secretion_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008672I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased interleukin-17 secretion_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008681I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased interleukin-4 secretion_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008699I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased interleukin-5 secretion_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0008702I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta
• increased regulatory T cell apoptosis_Itch<tm1.1Alta>/Itch<tm1.1Alta>,Foxp3<tm4(YFP/icre)Ayr>/Foxp3<+>
  http://metadb.riken.jp/0012188I129S1Sv129X1SvJC57BL6Itchtm11AltaItchtm11AltaFoxp3tm4YFPicreAyrFoxp3Foxp3Foxp3tm4YFPicreAyrItchtm11Alta