Zheng. Chen, et.al., SH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion., Diabetes, 2014, 63

http://rdf.ncbi.nlm.nih.gov/pubmed/24150605

Zheng. Chen, et.al., SH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion., Diabetes, 2014, 63

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sh2b1<tm2.1Lr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5568997

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased pancreatic beta cell proliferation_Sh2b1<tm2.1Lr>/Sh2b1<tm2.1Lr>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0011819I129S1Sv129X1SvJC57BL6CBASJLSh2b1tm21LrSh2b1tm21LrTgPdx1cre891Dam0TgPdx1cre891DamSh2b1tm21Lr
• abnormal pancreatic beta cell physiology_Sh2b1<tm2.1Lr>/Sh2b1<tm2.1Lr>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0003562I129S1Sv129X1SvJC57BL6CBASJLSh2b1tm21LrSh2b1tm21LrTgPdx1cre891Dam0TgPdx1cre891DamSh2b1tm21Lr
• decreased circulating insulin level_Sh2b1<tm2.1Lr>/Sh2b1<tm2.1Lr>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0002727I129S1Sv129X1SvJC57BL6CBASJLSh2b1tm21LrSh2b1tm21LrTgPdx1cre891Dam0TgPdx1cre891DamSh2b1tm21Lr
• small pancreatic islets_Sh2b1<tm2.1Lr>/Sh2b1<tm2.1Lr>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009172I129S1Sv129X1SvJC57BL6CBASJLSh2b1tm21LrSh2b1tm21LrTgPdx1cre891Dam0TgPdx1cre891DamSh2b1tm21Lr
• decreased insulin secretion_Sh2b1<tm2.1Lr>/Sh2b1<tm2.1Lr>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0003059I129S1Sv129X1SvJC57BL6CBASJLSh2b1tm21LrSh2b1tm21LrTgPdx1cre891Dam0TgPdx1cre891DamSh2b1tm21Lr
• impaired glucose tolerance_Sh2b1<tm2.1Lr>/Sh2b1<tm2.1Lr>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0005293I129S1Sv129X1SvJC57BL6CBASJLSh2b1tm21LrSh2b1tm21LrTgPdx1cre891Dam0TgPdx1cre891DamSh2b1tm21Lr
• decreased pancreatic beta cell mass_Sh2b1<tm2.1Lr>/Sh2b1<tm2.1Lr>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009114I129S1Sv129X1SvJC57BL6CBASJLSh2b1tm21LrSh2b1tm21LrTgPdx1cre891Dam0TgPdx1cre891DamSh2b1tm21Lr
• increased circulating glucose level_Sh2b1<tm2.1Lr>/Sh2b1<tm2.1Lr>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0005559I129S1Sv129X1SvJC57BL6CBASJLSh2b1tm21LrSh2b1tm21LrTgPdx1cre891Dam0TgPdx1cre891DamSh2b1tm21Lr

class

http://purl.org/net/cito/citesAsAuthority

• Sh2b1<tm2.1Lr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5568997