Eric D. Berglund, et.al., Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis., The Journal of clinical investigation, 2013, 123

http://rdf.ncbi.nlm.nih.gov/pubmed/24177424

Eric D. Berglund, et.al., Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis., The Journal of clinical investigation, 2013, 123

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Pomc-cre/ERT2)#Jke
  http://metadb.riken.jp/db/mgi_rdf/MGI:5569339
• Htr2c<tm2Jke>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5569357

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Pomc-cre/ERT2)#Jke
  http://metadb.riken.jp/db/mgi_rdf/MGI:5569339
• Htr2c<tm2Jke>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5569357

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating insulin level_Htr2c<tm2Jke>/Y,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0002079I129X1SvJC57BL6JHtr2ctm2JkeYTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• increased body weight_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0001260I129X1SvJC57BL6JHtr2ctm2JkeHtr2ctm2JkeTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• increased body weight_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001260I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased oxygen consumption_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0005289I129X1SvJC57BL6JHtr2ctm2JkeHtr2ctm2JkeTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• premature death_Htr2c<tm2Jke>/Y,Tg(Zp3-cre)93Knw/0
  http://metadb.riken.jp/0002083I129X1SvJC57BL6JHtr2ctm2JkeYTgZp3cre93Knw0Htr2ctm2JkeTgZp3cre93Knw
• increased oxygen consumption_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005289I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased body weight_Htr2c<tm2Jke>/Y,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0001260I129X1SvJC57BL6JHtr2ctm2JkeYTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• abnormal respiratory quotient_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0004129I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased body weight_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001260I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased energy expenditure_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0004889I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased food intake_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0011939I129X1SvJC57BL6JHtr2ctm2JkeHtr2ctm2JkeTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• abnormal locomotor activation_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0003313I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased circulating glucagon level_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002712I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased circulating glucagon level_Htr2c<tm2Jke>/Y,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0002712I129X1SvJC57BL6JHtr2ctm2JkeYTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• hyperactivity_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001399I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased food intake_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0011939I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased oxygen consumption_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005289I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• decreased oxygen consumption_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005290I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• hyperactivity_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001399I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• abnormal nervous system electrophysiology_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0,Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002272I129S6SvEvTac129X1SvJC57BL6FVBNHtr2ctm2JkeYTgPomc1cre16Lowl0GtROSA26Sortm14CAGtdTomatoHzeGtROSA26SorHtr2ctm2JkeGtROSA26SorTgPomc1cre16LowlGtROSA26Sortm14CAGtdTomatoHze
• increased circulating insulin level_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002079I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• abnormal locomotor activation_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0003313I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• hyperglycemia_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001559I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• seizures_Htr2c<tm2Jke>/Y,Tg(Zp3-cre)93Knw/0
  http://metadb.riken.jp/0002064I129X1SvJC57BL6JHtr2ctm2JkeYTgZp3cre93Knw0Htr2ctm2JkeTgZp3cre93Knw
• increased energy expenditure_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0004889I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased food intake_Htr2c<tm2Jke>/Y,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0011939I129X1SvJC57BL6JHtr2ctm2JkeYTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• increased food intake_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0011939I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased susceptibility to diet-induced obesity_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005658I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• hyperglycemia_Htr2c<tm2Jke>/Y,Tg(Zp3-cre)93Knw/0
  http://metadb.riken.jp/0001559I129X1SvJC57BL6JHtr2ctm2JkeYTgZp3cre93Knw0Htr2ctm2JkeTgZp3cre93Knw
• increased circulating glucose level_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005559I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• abnormal respiratory quotient_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0004129I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased oxygen consumption_Htr2c<tm2Jke>/Y,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0005289I129X1SvJC57BL6JHtr2ctm2JkeYTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• hyperglycemia_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001559I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased circulating glucose level_Htr2c<tm2Jke>/Y,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0005559I129X1SvJC57BL6JHtr2ctm2JkeYTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• increased susceptibility to diet-induced obesity_Htr2c<tm2Jke>/Y,Tg(Zp3-cre)93Knw/0
  http://metadb.riken.jp/0005658I129X1SvJC57BL6JHtr2ctm2JkeYTgZp3cre93Knw0Htr2ctm2JkeTgZp3cre93Knw
• increased susceptibility to diet-induced obesity_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005658I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased circulating insulin level_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002079I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• insulin resistance_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005331I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased circulating glucose level_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005559I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased circulating insulin level_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0002079I129X1SvJC57BL6JHtr2ctm2JkeHtr2ctm2JkeTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• increased circulating glucose level_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0005559I129X1SvJC57BL6JHtr2ctm2JkeHtr2ctm2JkeTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke
• increased circulating glucagon level_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002712I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• insulin resistance_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005331I129X1SvJC57BL6JFVBNHtr2ctm2JkeHtr2ctm2JkeTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• decreased oxygen consumption_Htr2c<tm2Jke>/Y,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005290I129X1SvJC57BL6JFVBNHtr2ctm2JkeYTgPomc1cre16Lowl0TgPomc1cre16LowlHtr2ctm2Jke
• increased circulating glucagon level_Htr2c<tm2Jke>/Htr2c<tm2Jke>,Tg(Pomc-cre/ERT2)#Jke/0
  http://metadb.riken.jp/0002712I129X1SvJC57BL6JHtr2ctm2JkeHtr2ctm2JkeTgPomccreERT2Jke0TgPomccreERT2JkeHtr2ctm2Jke