Yeon Sook. Choi, et.al., Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis., Cell stem cell, 2013, 13

http://rdf.ncbi.nlm.nih.gov/pubmed/24315444

Yeon Sook. Choi, et.al., Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis., Cell stem cell, 2013, 13

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Axin2<tm1.1(cre/ERT2/tdTomato)Smr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5532194
• Tg(KRT14-Kremen1)1Smr
  http://metadb.riken.jp/db/mgi_rdf/MGI:5538306

class

http://purl.org/net/cito/citesAsAuthority

• Axin2<tm1.1(cre/ERT2/tdTomato)Smr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5532194
• Tg(KRT14-Kremen1)1Smr
  http://metadb.riken.jp/db/mgi_rdf/MGI:5538306

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased hair follicle number_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0000379I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• abnormal hair cycle anagen phase_Tg(KRT5-rtTA)#Glk/0,Tg(tetO-Dkk1)1Smr/0
  http://metadb.riken.jp/0008858IC57BL6FVBNSJLTgKRT5rtTAGlk0TgtetODkk11Smr0TgKRT5rtTAGlkTgtetODkk11Smr
• abnormal epidermal layer morphology_Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wls<tm1.1Lan>/Wls<tm1.1Lan>
  http://metadb.riken.jp/0001216I129S6SvEvTacC57BL6FVBNTgKRT5rtTAGlk0TgtetOcre1Jaw0Wlstm11LanWlstm11LanTgKRT5rtTAGlkWlstm11LanTgtetOcre1Jaw
• abnormal dermis papillary layer morphology_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0009545I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• abnormal epidermal layer morphology_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0001216I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• abnormal keratinocyte morphology_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0002655I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• accelerated hair follicle regression_Tg(KRT5-rtTA)#Glk/0,Tg(tetO-Dkk1)1Smr/0
  http://metadb.riken.jp/0000392IC57BL6FVBNSJLTgKRT5rtTAGlk0TgtetODkk11Smr0TgKRT5rtTAGlkTgtetODkk11Smr
• abnormal hair follicle morphology_Tg(KRT14-Kremen1)1Smr/0,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-Dkk1)1Smr/0
  http://metadb.riken.jp/0000377IC57BL6FVBNSJLTgKRT14Kremen11Smr0TgKRT5rtTAGlk0TgtetODkk11Smr0TgtetODkk11SmrTgKRT5rtTAGlkTgKRT14Kremen11Smr
• abnormal hair cycle anagen phase_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0008858I129S1Sv129X1SvJC57BL6SJLCtnnb1tm2KemCtnnb1tm2KemTgKrt115crePGR22Cot0Ctnnb1tm2KemTgKrt115crePGR22Cot
• abnormal hair growth_Tg(KRT5-rtTA)#Glk/0,Tg(tetO-Dkk1)1Smr/0
  http://metadb.riken.jp/0002073IC57BL6FVBNSJLTgKRT5rtTAGlk0TgtetODkk11Smr0TgKRT5rtTAGlkTgtetODkk11Smr
• abnormal hair cycle catagen phase_Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wls<tm1.1Lan>/Wls<tm1.1Lan>
  http://metadb.riken.jp/0008859I129S6SvEvTacC57BL6FVBNTgKRT5rtTAGlk0TgtetOcre1Jaw0Wlstm11LanWlstm11LanTgKRT5rtTAGlkWlstm11LanTgtetOcre1Jaw
• accelerated hair follicle regression_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0000392I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• decreased cell proliferation_Axin2<tm1.1(cre/ERT2/tdTomato)Smr>/Axin2<+>,Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>
  http://metadb.riken.jp/0000352I129S2SvPasC57BL6Axin2tm11creERT2tdTomatoSmrAxin2Ctnnb1tm2KemCtnnb1tm2KemCtnnb1tm2KemAxin2tm11creERT2tdTomatoSmrAxin2
• thick epidermis suprabasal layer_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0009612I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• abnormal hair cycle anagen phase_Tg(KRT14-Kremen1)1Smr/0,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-Dkk1)1Smr/0
  http://metadb.riken.jp/0008858IC57BL6FVBNSJLTgKRT14Kremen11Smr0TgKRT5rtTAGlk0TgtetODkk11Smr0TgtetODkk11SmrTgKRT5rtTAGlkTgKRT14Kremen11Smr
• abnormal hair follicle morphology_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0000377I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• abnormal hair growth_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0002073I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• abnormal hair follicle morphology_Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wls<tm1.1Lan>/Wls<tm1.1Lan>
  http://metadb.riken.jp/0000377I129S6SvEvTacC57BL6FVBNTgKRT5rtTAGlk0TgtetOcre1Jaw0Wlstm11LanWlstm11LanTgKRT5rtTAGlkWlstm11LanTgtetOcre1Jaw
• thick epidermis_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0001219I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• increased mast cell number_Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wls<tm1.1Lan>/Wls<tm1.1Lan>
  http://metadb.riken.jp/0000324I129S6SvEvTacC57BL6FVBNTgKRT5rtTAGlk0TgtetOcre1Jaw0Wlstm11LanWlstm11LanTgKRT5rtTAGlkWlstm11LanTgtetOcre1Jaw
• abnormal hair growth_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0002073I129S1Sv129X1SvJC57BL6SJLCtnnb1tm2KemCtnnb1tm2KemTgKrt115crePGR22Cot0Ctnnb1tm2KemTgKrt115crePGR22Cot
• thick epidermis stratum basale_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0009715I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• abnormal hair cycle anagen phase_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0008858I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• abnormal keratinocyte morphology_Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0,Wls<tm1.1Lan>/Wls<tm1.1Lan>
  http://metadb.riken.jp/0002655I129S6SvEvTacC57BL6FVBNTgKRT5rtTAGlk0TgtetOcre1Jaw0Wlstm11LanWlstm11LanTgKRT5rtTAGlkWlstm11LanTgtetOcre1Jaw
• abnormal hair follicle morphology_Tg(KRT5-rtTA)#Glk/0,Tg(tetO-Dkk1)1Smr/0
  http://metadb.riken.jp/0000377IC57BL6FVBNSJLTgKRT5rtTAGlk0TgtetODkk11Smr0TgKRT5rtTAGlkTgtetODkk11Smr
• increased mast cell number_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT14-cre/ERT)20Efu/0
  http://metadb.riken.jp/0000324I129S1Sv129X1SvJCD1Ctnnb1tm2KemCtnnb1tm2KemTgKRT14creERT20Efu0Ctnnb1tm2KemTgKRT14creERT20Efu
• hair follicle degeneration_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0003413I129S1Sv129X1SvJC57BL6FVBNCtnnb1tm2KemCtnnb1tm2KemTgKRT5rtTAGlk0TgtetOcre1Jaw0TgtetOcre1JawCtnnb1tm2KemTgKRT5rtTAGlk
• abnormal hair follicle morphology_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(Krt1-15-cre/PGR)22Cot/0
  http://metadb.riken.jp/0000377I129S1Sv129X1SvJC57BL6SJLCtnnb1tm2KemCtnnb1tm2KemTgKrt115crePGR22Cot0Ctnnb1tm2KemTgKrt115crePGR22Cot
• abnormal epidermal layer morphology_Ctnnb1<tm2Kem>/Ctnnb1<tm2Kem>,Tg(KRT14-cre/ERT)20Efu/0
  http://metadb.riken.jp/0001216I129S1Sv129X1SvJCD1Ctnnb1tm2KemCtnnb1tm2KemTgKRT14creERT20Efu0Ctnnb1tm2KemTgKRT14creERT20Efu
• accelerated hair follicle regression_Tg(KRT14-Kremen1)1Smr/0,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-Dkk1)1Smr/0
  http://metadb.riken.jp/0000392IC57BL6FVBNSJLTgKRT14Kremen11Smr0TgKRT5rtTAGlk0TgtetODkk11Smr0TgtetODkk11SmrTgKRT5rtTAGlkTgKRT14Kremen11Smr
• abnormal hair growth_Tg(KRT14-Kremen1)1Smr/0,Tg(KRT5-rtTA)#Glk/0,Tg(tetO-Dkk1)1Smr/0
  http://metadb.riken.jp/0002073IC57BL6FVBNSJLTgKRT14Kremen11Smr0TgKRT5rtTAGlk0TgtetODkk11Smr0TgtetODkk11SmrTgKRT5rtTAGlkTgKRT14Kremen11Smr