Sharona. Tornovsky-Babeay, et.al., Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells., Cell metabolism, 2014, 19

http://rdf.ncbi.nlm.nih.gov/pubmed/24332968

Sharona. Tornovsky-Babeay, et.al., Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells., Cell metabolism, 2014, 19

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(Gck)Ydor>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5581726

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(Gck)Ydor>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5581726

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hyperglycemia_Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>/Gt(ROSA)26Sor<+>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0001559I129S4SvJaeC57BL6CBAGtROSA26Sortm1Kcnj11V59MFmasGtROSA26SorTgPdx1creEsr1Dam0GtROSA26SorTgPdx1creEsr1DamGtROSA26Sortm1Kcnj11V59MFmas
• abnormal pancreatic beta cell physiology_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0003562IC57BL6CBAGtROSA26Sortm1GckYdorGtROSA26SorTgPdx1creEsr1Dam0GtROSA26Sortm1GckYdorTgPdx1creEsr1DamGtROSA26Sor
• postnatal lethality, incomplete penetrance_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0011086I129P2OlaHsdC57BL6DBAGtROSA26Sortm1GckYdorGtROSA26SorTrp53tm1BrnTrp53tm1BrnTgIns2cre25Mgn0GtROSA26Sortm1GckYdorTgIns2cre25MgnTrp53tm1BrnGtROSA26Sor
• abnormal pancreatic beta cell physiology_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0003562I129S4SvJaeC57BL6CBAGtROSA26Sortm1GckYdorGtROSA26Sortm1Kcnj11V59MFmasTgPdx1creEsr1Dam0TgPdx1creEsr1DamGtROSA26Sortm1GckYdorGtROSA26Sortm1Kcnj11V59MFmas
• hyperglycemia_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<tm1(Kcnj11*V59M)Fmas>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0001559I129S4SvJaeC57BL6CBAGtROSA26Sortm1GckYdorGtROSA26Sortm1Kcnj11V59MFmasTgPdx1creEsr1Dam0TgPdx1creEsr1DamGtROSA26Sortm1GckYdorGtROSA26Sortm1Kcnj11V59MFmas
• decreased circulating insulin level_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0002727IC57BL6DBAGtROSA26Sortm1GckYdorGtROSA26SorTgIns2cre25Mgn0GtROSA26Sortm1GckYdorTgIns2cre25MgnGtROSA26Sor
• decreased pancreatic beta cell mass_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0009114IC57BL6DBAGtROSA26Sortm1GckYdorGtROSA26SorTgIns2cre25Mgn0GtROSA26Sortm1GckYdorTgIns2cre25MgnGtROSA26Sor
• hyperglycemia_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0001559IC57BLKSJLeprdbLeprdbLeprdb
• hyperglycemia_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001559IC57BL6DBAGtROSA26Sortm1GckYdorGtROSA26SorTgIns2cre25Mgn0GtROSA26Sortm1GckYdorTgIns2cre25MgnGtROSA26Sor
• postnatal lethality, incomplete penetrance_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0011086IC57BL6DBAGtROSA26Sortm1GckYdorGtROSA26SorTgIns2cre25Mgn0GtROSA26Sortm1GckYdorTgIns2cre25MgnGtROSA26Sor
• decreased pancreatic beta cell proliferation_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0011820IC57BL6CBAGtROSA26Sortm1GckYdorGtROSA26SorTgPdx1creEsr1Dam0GtROSA26Sortm1GckYdorTgPdx1creEsr1DamGtROSA26Sor
• hyperglycemia_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001559I129P2OlaHsdC57BL6DBAGtROSA26Sortm1GckYdorGtROSA26SorTrp53tm1BrnTrp53tm1BrnTgIns2cre25Mgn0GtROSA26Sortm1GckYdorTgIns2cre25MgnTrp53tm1BrnGtROSA26Sor
• increased oxygen consumption_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0005289IC57BL6CBAGtROSA26Sortm1GckYdorGtROSA26SorTgPdx1creEsr1Dam0GtROSA26Sortm1GckYdorTgPdx1creEsr1DamGtROSA26Sor
• increased circulating insulin level_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0002079IC57BL6CBAGtROSA26Sortm1GckYdorGtROSA26SorTgPdx1creEsr1Dam0GtROSA26Sortm1GckYdorTgPdx1creEsr1DamGtROSA26Sor
• abnormal pancreatic beta cell physiology_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0003562IC57BLKSJLeprdbLeprdbLeprdb
• decreased fasted circulating glucose level_Gt(ROSA)26Sor<tm1(Gck)Ydor>/Gt(ROSA)26Sor<+>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0013278IC57BL6CBAGtROSA26Sortm1GckYdorGtROSA26SorTgPdx1creEsr1Dam0GtROSA26Sortm1GckYdorTgPdx1creEsr1DamGtROSA26Sor