Lucie P. Pellissier, et.al., Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis., PLoS genetics, 2013, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/24339791

Lucie P. Pellissier, et.al., Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis., PLoS genetics, 2013, 9

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal retinal photoreceptor layer morphology_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0003728I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• abnormal retina morphology_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0001325I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• decreased retinal apoptosis_Crb1<tm1Wij>/Crb1<+>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0030006I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1Crb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0TgChx10EGFPcreALPP2ClcCrb2tm11WijCrb1tm1WijCrb1
• abnormal retina outer limiting membrane morphology_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0010236I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• abnormal eye physiology_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0005253I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• decreased total retina thickness_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0011965I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• increased total retina thickness_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0011964I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• increased retinal apoptosis_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0030005I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• retinal degeneration_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0001326I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• disorganized retinal layers_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0001328I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• abnormal retinal ganglion layer morphology_Crb1<tm1Wij>/Crb1<+>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0005241I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1Crb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0TgChx10EGFPcreALPP2ClcCrb2tm11WijCrb1tm1WijCrb1
• abnormal eye physiology_Crb1<tm1Wij>/Crb1<+>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0005253I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1Crb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0TgChx10EGFPcreALPP2ClcCrb2tm11WijCrb1tm1WijCrb1
• abnormal Muller cell morphology_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0005547I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• abnormal retinal bipolar cell morphology_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0006073I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• abnormal retinal layer morphology_Crb1<tm1Wij>/Crb1<+>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0003727I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1Crb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0TgChx10EGFPcreALPP2ClcCrb2tm11WijCrb1tm1WijCrb1
• increased retinal apoptosis_Crb1<tm1Wij>/Crb1<+>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0030005I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1Crb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0TgChx10EGFPcreALPP2ClcCrb2tm11WijCrb1tm1WijCrb1
• abnormal retinal photoreceptor layer morphology_Crb1<tm1Wij>/Crb1<+>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0003728I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1Crb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0TgChx10EGFPcreALPP2ClcCrb2tm11WijCrb1tm1WijCrb1
• increased amacrine cell number_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0008105I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• increased retinal rod cell number_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0008452I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• abnormal retina morphology_Crb1<tm1Wij>/Crb1<+>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0001325I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1Crb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0TgChx10EGFPcreALPP2ClcCrb2tm11WijCrb1tm1WijCrb1
• abnormal electroretinogram waveform feature_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0012029I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• abnormal retina outer limiting membrane morphology_Crb1<tm1Wij>/Crb1<+>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0010236I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1Crb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0TgChx10EGFPcreALPP2ClcCrb2tm11WijCrb1tm1WijCrb1
• abnormal retinal layer morphology_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0003727I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• abnormal electroretinogram waveform feature_Crb1<tm1Wij>/Crb1<+>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0012029I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1Crb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0TgChx10EGFPcreALPP2ClcCrb2tm11WijCrb1tm1WijCrb1
• abnormal retinal progenitor cell morphology_Crb1<tm1Wij>/Crb1<tm1Wij>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0006071I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1tm1WijCrb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0Crb1tm1WijTgChx10EGFPcreALPP2ClcCrb2tm11Wij
• abnormal retinal development_Crb1<tm1Wij>/Crb1<+>,Crb2<tm1.1Wij>/Crb2<tm1.1Wij>,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
  http://metadb.riken.jp/0009772I129P2OlaHsdC57BL6C57BL6JOlaHsdSJLCrb1tm1WijCrb1Crb2tm11WijCrb2tm11WijTgChx10EGFPcreALPP2Clc0TgChx10EGFPcreALPP2ClcCrb2tm11WijCrb1tm1WijCrb1