Lev M. Kats, et.al., Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance., Cell stem cell, 2014, 14

http://rdf.ncbi.nlm.nih.gov/pubmed/24440599

Lev M. Kats, et.al., Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance., Cell stem cell, 2014, 14

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm2(tetO-IDH2*R140Q)Ppp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5617498

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm2(tetO-IDH2*R140Q)Ppp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5617498

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal hematopoietic stem cell proliferation_Col1a1<tm2(tetO-IDH2*R140Q)Ppp>/Col1a1<tm2(tetO-IDH2*R140Q)Ppp>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/?
  http://metadb.riken.jp/0011901I129S4SvJaeC57BL6Col1a1tm2tetOIDH2R140QPppCol1a1tm2tetOIDH2R140QPppGtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOIDH2R140QPppGtROSA26Sortm1rtTAM2Jae
• premature death_Col1a1<tm2(tetO-IDH2*R140Q)Ppp>/Col1a1<tm2(tetO-IDH2*R140Q)Ppp>,Flt3<tm1.1Dosm>/Flt3<tm1.1Dosm>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/?
  http://metadb.riken.jp/0002083I129C57BL6Col1a1tm2tetOIDH2R140QPppCol1a1tm2tetOIDH2R140QPppFlt3tm11DosmFlt3tm11DosmGtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOIDH2R140QPppFlt3tm11DosmGtROSA26Sortm1rtTAM2Jae
• increased leukemia incidence_Col1a1<tm2(tetO-IDH2*R140Q)Ppp>/Col1a1<tm2(tetO-IDH2*R140Q)Ppp>,Flt3<tm1.1Dosm>/Flt3<tm1.1Dosm>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/?
  http://metadb.riken.jp/0002026I129C57BL6Col1a1tm2tetOIDH2R140QPppCol1a1tm2tetOIDH2R140QPppFlt3tm11DosmFlt3tm11DosmGtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOIDH2R140QPppFlt3tm11DosmGtROSA26Sortm1rtTAM2Jae
• extramedullary hematopoiesis_Col1a1<tm2(tetO-IDH2*R140Q)Ppp>/Col1a1<tm2(tetO-IDH2*R140Q)Ppp>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/?
  http://metadb.riken.jp/0000240I129S4SvJaeC57BL6Col1a1tm2tetOIDH2R140QPppCol1a1tm2tetOIDH2R140QPppGtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOIDH2R140QPppGtROSA26Sortm1rtTAM2Jae
• increased hematopoietic stem cell proliferation_Col1a1<tm2(tetO-IDH2*R140Q)Ppp>/Col1a1<tm2(tetO-IDH2*R140Q)Ppp>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/?
  http://metadb.riken.jp/0011902I129S4SvJaeC57BL6Col1a1tm2tetOIDH2R140QPppCol1a1tm2tetOIDH2R140QPppGtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOIDH2R140QPppGtROSA26Sortm1rtTAM2Jae
• increased leukemia incidence_Col1a1<tm2(tetO-IDH2*R140Q)Ppp>/Col1a1<tm2(tetO-IDH2*R140Q)Ppp>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/?
  http://metadb.riken.jp/0002026I129S4SvJaeC57BL6Col1a1tm2tetOIDH2R140QPppCol1a1tm2tetOIDH2R140QPppGtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOIDH2R140QPppGtROSA26Sortm1rtTAM2Jae
• enlarged spleen_Col1a1<tm2(tetO-IDH2*R140Q)Ppp>/Col1a1<tm2(tetO-IDH2*R140Q)Ppp>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/?
  http://metadb.riken.jp/0000691I129S4SvJaeC57BL6Col1a1tm2tetOIDH2R140QPppCol1a1tm2tetOIDH2R140QPppGtROSA26Sortm1rtTAM2JaeCol1a1tm2tetOIDH2R140QPppGtROSA26Sortm1rtTAM2Jae