Pamela V. Tran, et.al., Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models., Journal of the American Society of Nephrology : JASN, 2014, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/24700869

Pamela V. Tran, et.al., Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models., Journal of the American Society of Nephrology : JASN, 2014, 25

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ttc21b<tm2c(KOMP)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5587034

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased kidney cell proliferation_Ttc21b<tm2c(KOMP)Wtsi>/Ttc21b<aln>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0011440I129S1Sv129X1SvJC57BL6NTtc21btm2cKOMPWtsiTtc21balnGtROSA26Sortm1creERTNatGtROSA26SorTtc21btm2cKOMPWtsiTtc21balnGtROSA26SorGtROSA26Sortm1creERTNat
• increased kidney weight_Nek8<jck>/Nek8<jck>
  http://metadb.riken.jp/0003917IC57BL6JNek8jckNek8jckNek8jck
• increased kidney weight_Ttc21b<tm2c(KOMP)Wtsi>/Ttc21b<aln>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003917I129S1Sv129X1SvJC57BL6NTtc21btm2cKOMPWtsiTtc21balnGtROSA26Sortm1creERTNatGtROSA26SorTtc21btm2cKOMPWtsiTtc21balnGtROSA26SorGtROSA26Sortm1creERTNat
• dilated proximal convoluted tubules_Ttc21b<tm2c(KOMP)Wtsi>/Ttc21b<aln>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0009050I129S1Sv129X1SvJC57BL6NTtc21btm2cKOMPWtsiTtc21balnGtROSA26Sortm1creERTNatGtROSA26SorTtc21btm2cKOMPWtsiTtc21balnGtROSA26SorGtROSA26Sortm1creERTNat
• increased blood urea nitrogen level_Ttc21b<tm2c(KOMP)Wtsi>/Ttc21b<aln>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005565I129S1Sv129X1SvJC57BL6NTtc21btm2cKOMPWtsiTtc21balnGtROSA26Sortm1creERTNatGtROSA26SorTtc21btm2cKOMPWtsiTtc21balnGtROSA26SorGtROSA26Sortm1creERTNat
• abnormal loop of Henle morphology_Ttc21b<tm2c(KOMP)Wtsi>/Ttc21b<aln>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004755I129S1Sv129X1SvJC57BL6NTtc21btm2cKOMPWtsiTtc21balnGtROSA26Sortm1creERTNatGtROSA26SorTtc21btm2cKOMPWtsiTtc21balnGtROSA26SorGtROSA26Sortm1creERTNat
• polycystic kidney_Ttc21b<aln>/Ttc21b<aln>
  http://metadb.riken.jp/0008528NSTtc21balnTtc21balnTtc21baln
• polycystic kidney_Ttc21b<tm2c(KOMP)Wtsi>/Ttc21b<aln>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008528I129S1Sv129X1SvJC57BL6NTtc21btm2cKOMPWtsiTtc21balnGtROSA26Sortm1creERTNatGtROSA26SorTtc21btm2cKOMPWtsiTtc21balnGtROSA26SorGtROSA26Sortm1creERTNat
• abnormal kidney morphology_Ttc21b<tm2c(KOMP)Wtsi>/Ttc21b<aln>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002135I129S1Sv129X1SvJC57BL6NTtc21btm2cKOMPWtsiTtc21balnGtROSA26Sortm1creERTNatGtROSA26SorTtc21btm2cKOMPWtsiTtc21balnGtROSA26SorGtROSA26Sortm1creERTNat
• increased kidney weight_Pkd1<tm2Ggg>/Pkd1<tm2Ggg>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003917I129S1Sv129S4SvJae129X1SvJC57BL6Pkd1tm2GggPkd1tm2GggGtROSA26Sortm1creERTNatGtROSA26SorGtROSA26Sortm1creERTNatGtROSA26SorPkd1tm2Ggg
• kidney cysts_Pkd1<m1Bei>/Pkd1<m1Bei>
  http://metadb.riken.jp/0003675IAJFVBNPkd1m1BeiPkd1m1BeiPkd1m1Bei
• polycystic kidney_Nek8<jck>/Nek8<jck>
  http://metadb.riken.jp/0008528IC57BL6JNek8jckNek8jckNek8jck
• decreased kidney epithelial cell primary cilium length_Ttc21b<tm2c(KOMP)Wtsi>/Ttc21b<aln>,Gt(ROSA)26Sor<tm1(cre/ERT)Nat>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0020383I129S1Sv129X1SvJC57BL6NTtc21btm2cKOMPWtsiTtc21balnGtROSA26Sortm1creERTNatGtROSA26SorTtc21btm2cKOMPWtsiTtc21balnGtROSA26SorGtROSA26Sortm1creERTNat

class

http://purl.org/net/cito/citesAsAuthority

• Ttc21b<tm2c(KOMP)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5587034