Achia. Urbach, et.al., Lin28 sustains early renal progenitors and induces Wilms tumor., Genes & development, 2014, 28

http://rdf.ncbi.nlm.nih.gov/pubmed/24732380

Achia. Urbach, et.al., Lin28 sustains early renal progenitors and induces Wilms tumor., Genes & development, 2014, 28

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(EIF1AX-Lin28a)#Gqda
  http://metadb.riken.jp/db/mgi_rdf/MGI:5634777

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• perinatal lethality_Tg(Ddx4-cre)1Dcas/0,Tg(EIF1AX-Lin28a)#Gqda/0
  http://metadb.riken.jp/0002081I129S4SvJaeC57BL6CD1FVBNTgDdx4cre1Dcas0TgEIF1AXLin28aGqda0TgEIF1AXLin28aGqdaTgDdx4cre1Dcas
• kidney cysts_Tg(EIF1AX-Lin28a)#Gqda/0,Tg(Six2-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0003675I129S4SvJaeC57BL6CD1TgEIF1AXLin28aGqda0TgSix2EGFPcre1Amc0TgSix2EGFPcre1AmcTgEIF1AXLin28aGqda
• abnormal kidney mesenchyme morphology_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Wt1<tm2(cre/ERT2)Wtp>/Wt1<+>
  http://metadb.riken.jp/0010985I129S1Sv129S4SvJae129X1SvJC57BL6Col1a1tm2tetOLIN28BGqdaCol1a1GtROSA26Sortm1rtTAEGFPNagyGtROSA26SorWt1tm2creERT2WtpWt1GtROSA26SorCol1a1tm2tetOLIN28BGqdaWt1Col1a1Wt1tm2creERT2WtpGtROSA26Sortm1rtTAEGFPNagy
• small kidney_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<tm3(tetO-Mirlet7g/Mir21)Gqda>,Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Wt1<tm2(cre/ERT2)Wtp>/Wt1<+>
  http://metadb.riken.jp/0002989I129S1Sv129S4SvJae129X1SvJC57BL6Col1a1tm2tetOLIN28BGqdaCol1a1tm3tetOMirlet7gMir21GqdaGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorWt1tm2creERT2WtpWt1Col1a1tm3tetOMirlet7gMir21GqdaGtROSA26Sortm1rtTAEGFPNagyWt1tm2creERT2WtpWt1Col1a1tm2tetOLIN28BGqdaGtROSA26Sor
• enlarged kidney_Tg(Ddx4-cre)1Dcas/0,Tg(EIF1AX-Lin28a)#Gqda/0
  http://metadb.riken.jp/0003068I129S4SvJaeC57BL6CD1FVBNTgDdx4cre1Dcas0TgEIF1AXLin28aGqda0TgEIF1AXLin28aGqdaTgDdx4cre1Dcas
• delayed kidney development_Tg(Ddx4-cre)1Dcas/0,Tg(EIF1AX-Lin28a)#Gqda/0
  http://metadb.riken.jp/0000528I129S4SvJaeC57BL6CD1FVBNTgDdx4cre1Dcas0TgEIF1AXLin28aGqda0TgEIF1AXLin28aGqdaTgDdx4cre1Dcas
• abnormal proximal convoluted tubule morphology_Tg(Ddx4-cre)1Dcas/0,Tg(EIF1AX-Lin28a)#Gqda/0
  http://metadb.riken.jp/0004756I129S4SvJaeC57BL6CD1FVBNTgDdx4cre1Dcas0TgEIF1AXLin28aGqda0TgEIF1AXLin28aGqdaTgDdx4cre1Dcas
• increased kidney tumor incidence_Tg(Ddx4-cre)1Dcas/0,Tg(EIF1AX-Lin28a)#Gqda/0
  http://metadb.riken.jp/0010294I129S4SvJaeC57BL6CD1FVBNTgDdx4cre1Dcas0TgEIF1AXLin28aGqda0TgEIF1AXLin28aGqdaTgDdx4cre1Dcas
• increased kidney tumor incidence_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Wt1<tm2(cre/ERT2)Wtp>/Wt1<+>
  http://metadb.riken.jp/0010294I129S1Sv129S4SvJae129X1SvJC57BL6Col1a1tm2tetOLIN28BGqdaCol1a1GtROSA26Sortm1rtTAEGFPNagyGtROSA26SorWt1tm2creERT2WtpWt1GtROSA26SorCol1a1tm2tetOLIN28BGqdaWt1Col1a1Wt1tm2creERT2WtpGtROSA26Sortm1rtTAEGFPNagy
• kidney cysts_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Wt1<tm2(cre/ERT2)Wtp>/Wt1<+>
  http://metadb.riken.jp/0003675I129S1Sv129S4SvJae129X1SvJC57BL6Col1a1tm2tetOLIN28BGqdaCol1a1GtROSA26Sortm1rtTAEGFPNagyGtROSA26SorWt1tm2creERT2WtpWt1GtROSA26SorCol1a1tm2tetOLIN28BGqdaWt1Col1a1Wt1tm2creERT2WtpGtROSA26Sortm1rtTAEGFPNagy
• delayed kidney development_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Wt1<tm2(cre/ERT2)Wtp>/Wt1<+>
  http://metadb.riken.jp/0000528I129S1Sv129S4SvJae129X1SvJC57BL6Col1a1tm2tetOLIN28BGqdaCol1a1GtROSA26Sortm1rtTAEGFPNagyGtROSA26SorWt1tm2creERT2WtpWt1GtROSA26SorCol1a1tm2tetOLIN28BGqdaWt1Col1a1Wt1tm2creERT2WtpGtROSA26Sortm1rtTAEGFPNagy
• abnormal kidney mesenchyme morphology_Tg(Ddx4-cre)1Dcas/0,Tg(EIF1AX-Lin28a)#Gqda/0
  http://metadb.riken.jp/0010985I129S4SvJaeC57BL6CD1FVBNTgDdx4cre1Dcas0TgEIF1AXLin28aGqda0TgEIF1AXLin28aGqdaTgDdx4cre1Dcas
• hydronephrosis_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<+>,Foxd1<tm1(GFP/cre)Amc>/Foxd1<+>,Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000519I129S1Sv129S4SvJae129X1SvJC57BL6Col1a1tm2tetOLIN28BGqdaCol1a1Foxd1tm1GFPcreAmcFoxd1GtROSA26Sortm1rtTAEGFPNagyGtROSA26SorGtROSA26Sortm1rtTAEGFPNagyFoxd1tm1GFPcreAmcCol1a1Col1a1tm2tetOLIN28BGqdaGtROSA26SorFoxd1
• kidney cysts_Col1a1<tm2(tetO-LIN28B)Gqda>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Tg(Six2-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0003675I129S1Sv129S4SvJae129X1SvJC57BL6CD1Col1a1tm2tetOLIN28BGqdaCol1a1GtROSA26Sortm1rtTAEGFPNagyGtROSA26SorTgSix2EGFPcre1Amc0GtROSA26SorCol1a1tm2tetOLIN28BGqdaCol1a1GtROSA26Sortm1rtTAEGFPNagyTgSix2EGFPcre1Amc

class

http://purl.org/net/cito/citesAsAuthority

• Tg(EIF1AX-Lin28a)#Gqda
  http://metadb.riken.jp/db/mgi_rdf/MGI:5634777