Nan. Wang, et.al., Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease., Nature medicine, 2014, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/24784230

Nan. Wang, et.al., Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease., Nature medicine, 2014, 20

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased forebrain size_Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0012138FVBTgHTT97QIXwyTgHTT97QIXwy0TgHTT97QIXwy
• forebrain atrophy_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0012508IFVBRgs9tm1creYqlRgs9TgHTT97QIXwy0Rgs9TgHTT97QIXwyRgs9tm1creYql
• abnormal inhibitory postsynaptic currents_Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0002945FVBTgHTT97QIXwyTgHTT97QIXwy0TgHTT97QIXwy
• reduced NMDA-mediated synaptic currents_Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0001902FVBTgHTT97QIXwyTgHTT97QIXwy0TgHTT97QIXwy
• hypoactivity_Emx1<tm1(cre)Ito>/Emx1<+>,Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0001402I129P2OlaHsdFVBEmx1tm1creItoEmx1TgHTT97QIXwy0TgHTT97QIXwyEmx1Emx1tm1creIto
• forebrain atrophy_Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0012508FVBTgHTT97QIXwyTgHTT97QIXwy0TgHTT97QIXwy
• hypoactivity_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0001402IFVBRgs9tm1creYqlRgs9TgHTT97QIXwy0Rgs9TgHTT97QIXwyRgs9tm1creYql
• impaired coordination_Emx1<tm1(cre)Ito>/Emx1<+>,Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0001405I129P2OlaHsdFVBEmx1tm1creItoEmx1TgHTT97QIXwy0TgHTT97QIXwyEmx1Emx1tm1creIto
• increased anxiety-related response_Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0001363FVBTgHTT97QIXwyTgHTT97QIXwy0TgHTT97QIXwy
• abnormal excitatory postsynaptic currents_Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0002910FVBTgHTT97QIXwyTgHTT97QIXwy0TgHTT97QIXwy
• increased anxiety-related response_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0001363IFVBRgs9tm1creYqlRgs9TgHTT97QIXwy0Rgs9TgHTT97QIXwyRgs9tm1creYql
• impaired coordination_Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0001405FVBTgHTT97QIXwyTgHTT97QIXwy0TgHTT97QIXwy
• behavioral despair_Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0002573FVBTgHTT97QIXwyTgHTT97QIXwy0TgHTT97QIXwy
• impaired coordination_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0001405IFVBRgs9tm1creYqlRgs9TgHTT97QIXwy0Rgs9TgHTT97QIXwyRgs9tm1creYql
• behavioral despair_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(HTT*97Q)IXwy/0
  http://metadb.riken.jp/0002573IFVBRgs9tm1creYqlRgs9TgHTT97QIXwy0Rgs9TgHTT97QIXwyRgs9tm1creYql