Hidetoshi. Kassai, et.al., Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases., Cell reports, 2014, 7

http://rdf.ncbi.nlm.nih.gov/pubmed/24857653

Hidetoshi. Kassai, et.al., Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases., Cell reports, 2014, 7

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-Mtor*)#Atai
  http://metadb.riken.jp/db/mgi_rdf/MGI:5634714
• Tg(CAG-Mtor*)#Atai
  http://metadb.riken.jp/db/mgi_rdf/MGI:5634713

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-Mtor*)#Atai
  http://metadb.riken.jp/db/mgi_rdf/MGI:5634714
• Tg(CAG-Mtor*)#Atai
  http://metadb.riken.jp/db/mgi_rdf/MGI:5634713

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• neurodegeneration_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0002229IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• postnatal lethality_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0002082IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• thickened cerebral cortex_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0000789IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• microgliosis_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0008918IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• neuronal cytoplasmic inclusions_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0011975IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• megacephaly_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0000434IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• increased neuron apoptosis_Emx1<tm1(cre)Ito>/Emx1<+>,Tg(CAG-Mtor*)#Atai/0
  http://metadb.riken.jp/0003203I129P2OlaHsdC57BL6DBA2ICREmx1tm1creItoEmx1TgCAGMtorAtai0Emx1tm1creItoEmx1TgCAGMtorAtai
• decreased neuronal precursor cell number_Emx1<tm1(cre)Ito>/Emx1<+>,Tg(CAG-Mtor*)#Atai/0
  http://metadb.riken.jp/0004981I129P2OlaHsdC57BL6DBA2ICREmx1tm1creItoEmx1TgCAGMtorAtai0Emx1tm1creItoEmx1TgCAGMtorAtai
• postnatal growth retardation_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0001732IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• hypoactivity_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0001402IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• seizures_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0002064IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• small hippocampus_Emx1<tm1(cre)Ito>/Emx1<+>,Tg(CAG-Mtor*)#Atai/0
  http://metadb.riken.jp/0008283I129P2OlaHsdC57BL6DBA2ICREmx1tm1creItoEmx1TgCAGMtorAtai0Emx1tm1creItoEmx1TgCAGMtorAtai
• abnormal cerebral cortex morphology_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0000788IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• abnormal neuron morphology_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0002882IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• premature death_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-Mtor*)#Atai/0
  http://metadb.riken.jp/0002083IC57BL6DBA2ICRTgCamk2atTA1Mmay0TgtetOMtorAtai0TgtetOMtorAtaiTgCamk2atTA1Mmay
• abnormal cerebral cortex morphology_Emx1<tm1(cre)Ito>/Emx1<+>,Tg(CAG-Mtor*)#Atai/0
  http://metadb.riken.jp/0000788I129P2OlaHsdC57BL6DBA2ICREmx1tm1creItoEmx1TgCAGMtorAtai0Emx1tm1creItoEmx1TgCAGMtorAtai