Brooke. Tata, et.al., Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouse., PLoS biology, 2014, 12

http://rdf.ncbi.nlm.nih.gov/pubmed/25248098

Brooke. Tata, et.al., Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouse., PLoS biology, 2014, 12

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Dmxl2<tm1c(EUCOMM)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5705577

class

http://purl.org/net/cito/citesAsAuthority

• Dmxl2<tm1c(EUCOMM)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5705577

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• short perineum_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0003550IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• prenatal lethality, complete penetrance_Dmxl2<tm1a(EUCOMM)Wtsi>/Dmxl2<tm1a(EUCOMM)Wtsi>
  http://metadb.riken.jp/0011091IC57BL6NDmxl2tm1aEUCOMMWtsiDmxl2tm1aEUCOMMWtsiDmxl2tm1aEUCOMMWtsi
• decreased corpora lutea number_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0002680IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• reduced female fertility_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0001923IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• delayed sexual maturation_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0001938IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• decreased body weight_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0001262IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• abnormal hypothalamus secretion_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0001752IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• decreased ovulation rate_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0003355IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• reduced fertility_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0001921IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• delayed vaginal opening_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0002636IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• delayed estrous cycle_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0009008IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• increased circulating luteinizing hormone level_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0001751IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• short proestrus_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0009015IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• abnormal hypothalamus morphology_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0000837IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• abnormal estrous cycle_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0001927IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• increased exploration in new environment_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0001415IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• reduced male fertility_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0001922IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• decreased ovary weight_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0004856IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp
• decreased testis weight_Dmxl2<tm1c(EUCOMM)Wtsi>/Dmxl2<+>,Tg(Nes-cre)1Atp/0
  http://metadb.riken.jp/0004852IC57BL6NFVBNDmxl2tm1cEUCOMMWtsiDmxl2TgNescre1Atp0Dmxl2Dmxl2tm1cEUCOMMWtsiTgNescre1Atp