Suzana. Gispert, et.al., Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression., Human molecular genetics, 2015, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/25296918

Suzana. Gispert, et.al., Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression., Human molecular genetics, 2015, 24

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• neurodegeneration_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0002229I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• abnormal neurite morphology_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0008415I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• decreased stereotypic behavior_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0003908I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• abnormal motor neuron morphology_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0000937I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• alpha-synuclein inclusion body_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0008493I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• extended life span_Pink1<tm1Aub>/Pink1<tm1Aub>
  http://metadb.riken.jp/0001661I129SSvEvPink1tm1AubPink1tm1AubPink1tm1Aub
• kyphosis_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0000160I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• premature death_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0002083I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• paresis_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0000754I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• hypoactivity_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0001402I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• abnormal locomotor behavior_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0001392I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• premature death_Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0002083IFVBNTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAub
• hindlimb paralysis_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0000755I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub
• decreased vertical activity_Pink1<tm1Aub>/Pink1<tm1Aub>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0002757I129SSvEvFVBNPink1tm1AubPink1tm1AubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubPink1tm1AubTgPrnpSNCAA53TAAub