Shengfang. Jin, et.al., ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis., Proceedings of the National Academy of Sciences of the United States of America, 2015, 112

http://rdf.ncbi.nlm.nih.gov/pubmed/26150517

Shengfang. Jin, et.al., ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis., Proceedings of the National Academy of Sciences of the United States of America, 2015, 112

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Aldh2<tm1.1Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5701667

class

http://purl.org/net/cito/citesAsAuthority

• Aldh2<tm1.1Mak>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5701667

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hyperpigmentation_Aldh2<tm1.1Mak>/Aldh2<+>
  http://metadb.riken.jp/0001188I129S6SvEvTacC57BL6JAldh2tm11MakAldh2Aldh2Aldh2tm11Mak
• enhanced behavioral response to alcohol_Aldh2<tm1.1Mak>/Aldh2<tm1.1Mak>
  http://metadb.riken.jp/0009751I129S6SvEvTacC57BL6JAldh2tm11MakAldh2tm11MakAldh2tm11Mak
• decreased body weight_Aldh2<tm1.1Mak>/Aldh2<+>
  http://metadb.riken.jp/0001262I129S6SvEvTacC57BL6JAldh2tm11MakAldh2Aldh2Aldh2tm11Mak
• decreased tumor latency_Aldh2<tm1.1Mak>/Aldh2<tm1.1Mak>
  http://metadb.riken.jp/0010308I129S6SvEvTacC57BL6JAldh2tm11MakAldh2tm11MakAldh2tm11Mak
• abnormal enzyme/coenzyme activity_Aldh2<tm1.1Mak>/Aldh2<tm1.1Mak>
  http://metadb.riken.jp/0005584I129S6SvEvTacC57BL6JAldh2tm11MakAldh2tm11MakAldh2tm11Mak
• decreased body weight_Aldh2<tm1.1Mak>/Aldh2<tm1.1Mak>
  http://metadb.riken.jp/0001262I129S6SvEvTacC57BL6JAldh2tm11MakAldh2tm11MakAldh2tm11Mak
• increased sensitivity to induced morbidity/mortality_Aldh2<tm1.1Mak>/Aldh2<+>
  http://metadb.riken.jp/0009763I129S6SvEvTacC57BL6JAldh2tm11MakAldh2Aldh2Aldh2tm11Mak
• increased sensitivity to induced morbidity/mortality_Aldh2<tm1.1Mak>/Aldh2<tm1.1Mak>
  http://metadb.riken.jp/0009763I129S6SvEvTacC57BL6JAldh2tm11MakAldh2tm11MakAldh2tm11Mak
• enhanced behavioral response to alcohol_Aldh2<tm1.1Mak>/Aldh2<+>
  http://metadb.riken.jp/0009751I129S6SvEvTacC57BL6JAldh2tm11MakAldh2Aldh2Aldh2tm11Mak
• abnormal ethanol metabolism_Aldh2<tm1.1Mak>/Aldh2<tm1.1Mak>
  http://metadb.riken.jp/0005443I129S6SvEvTacC57BL6JAldh2tm11MakAldh2tm11MakAldh2tm11Mak
• abnormal ethanol metabolism_Aldh2<tm1.1Mak>/Aldh2<+>
  http://metadb.riken.jp/0005443I129S6SvEvTacC57BL6JAldh2tm11MakAldh2Aldh2Aldh2tm11Mak
• decreased leukocyte cell number_Aldh2<tm1.1Mak>/Aldh2<+>
  http://metadb.riken.jp/0000221I129S6SvEvTacC57BL6JAldh2tm11MakAldh2Aldh2Aldh2tm11Mak
• abnormal enzyme/coenzyme activity_Aldh2<tm1.1Mak>/Aldh2<+>
  http://metadb.riken.jp/0005584I129S6SvEvTacC57BL6JAldh2tm11MakAldh2Aldh2Aldh2tm11Mak
• increased incidence of tumors by chemical induction_Aldh2<tm1.1Mak>/Aldh2<+>
  http://metadb.riken.jp/0004499I129S6SvEvTacC57BL6JAldh2tm11MakAldh2Aldh2Aldh2tm11Mak
• increased incidence of tumors by chemical induction_Aldh2<tm1.1Mak>/Aldh2<tm1.1Mak>
  http://metadb.riken.jp/0004499I129S6SvEvTacC57BL6JAldh2tm11MakAldh2tm11MakAldh2tm11Mak
• increased hepatocyte apoptosis_Aldh2<tm1.1Mak>/Aldh2<tm1.1Mak>
  http://metadb.riken.jp/0003887I129S6SvEvTacC57BL6JAldh2tm11MakAldh2tm11MakAldh2tm11Mak
• hyperpigmentation_Aldh2<tm1.1Mak>/Aldh2<tm1.1Mak>
  http://metadb.riken.jp/0001188I129S6SvEvTacC57BL6JAldh2tm11MakAldh2tm11MakAldh2tm11Mak
• decreased leukocyte cell number_Aldh2<tm1.1Mak>/Aldh2<tm1.1Mak>
  http://metadb.riken.jp/0000221I129S6SvEvTacC57BL6JAldh2tm11MakAldh2tm11MakAldh2tm11Mak
• increased hepatocyte apoptosis_Aldh2<tm1.1Mak>/Aldh2<+>
  http://metadb.riken.jp/0003887I129S6SvEvTacC57BL6JAldh2tm11MakAldh2Aldh2Aldh2tm11Mak