Jonathan. Lévy, et.al., Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth., Nature cell biology, 2015, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/26214133

Jonathan. Lévy, et.al., Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth., Nature cell biology, 2015, 17

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal gut flora balance_Apc<tm2.1Cip>/Apc<+>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0010377I129P2OlaHsdC57BL6DBA2Apctm21CipApcTgVilcreERT223Syr0Apctm21CipApcTgVilcreERT223Syr
• abnormal Paneth cell morphology_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0004843I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc
• rectal prolapse_Apc<tm2.1Cip>/Apc<+>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0000493I129P2OlaHsdC57BL6DBA2Apctm21CipApcTgVilcreERT223Syr0Apctm21CipApcTgVilcreERT223Syr
• decreased intestinal adenoma incidence_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0012434I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc
• increased regulatory T cell number_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0004973I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc
• cachexia_Apc<tm2.1Cip>/Apc<+>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0005150I129P2OlaHsdC57BL6DBA2Apctm21CipApcTgVilcreERT223Syr0Apctm21CipApcTgVilcreERT223Syr
• intestine polyps_Apc<tm2.1Cip>/Apc<+>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0008011I129P2OlaHsdC57BL6DBA2Apctm21CipApcTgVilcreERT223Syr0Apctm21CipApcTgVilcreERT223Syr
• abnormal immune system physiology_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0001790I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc
• increased interleukin-1 beta secretion_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0008657I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc
• abnormal intestine physiology_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0010155I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc
• premature death_Apc<tm2.1Cip>/Apc<+>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6DBA2Apctm21CipApcTgVilcreERT223Syr0Apctm21CipApcTgVilcreERT223Syr
• increased intestinal adenoma incidence_Apc<tm2.1Cip>/Apc<+>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0002404I129P2OlaHsdC57BL6DBA2Apctm21CipApcTgVilcreERT223Syr0Apctm21CipApcTgVilcreERT223Syr
• increased CD103-positive CD11b-low dendritic cell number_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0013654I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc
• increased interleukin-10 secretion_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0008660I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc
• abnormal gut flora balance_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0010377I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc
• abnormal autophagy_Apc<tm2.1Cip>/Apc<+>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0008260I129P2OlaHsdC57BL6DBA2Apctm21CipApcTgVilcreERT223Syr0Apctm21CipApcTgVilcreERT223Syr
• increased colonic adenoma incidence_Apc<tm2.1Cip>/Apc<+>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0002044I129P2OlaHsdC57BL6DBA2Apctm21CipApcTgVilcreERT223Syr0Apctm21CipApcTgVilcreERT223Syr
• increased CD8-positive, alpha-beta T cell number_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0008078I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc
• abnormal intestinal goblet cell morphology_Apc<tm2.1Cip>/Apc<+>,Atg7<tm1Tchi>/Atg7<tm1Tchi>,Tg(Vil-cre/ERT2)23Syr/0
  http://metadb.riken.jp/0003449I129P2OlaHsdC57BL6C57BL6NCrljCBAJNCrljDBA2Apctm21CipApcAtg7tm1TchiAtg7tm1TchiTgVilcreERT223Syr0Atg7tm1TchiTgVilcreERT223SyrApctm21CipApc

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• intestine polyps in RBRC01872
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015055
• abnormal intestinal goblet cell morphology in RBRC01872
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015060
• abnormal autophagy in RBRC01872
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015057
• abnormal gut flora balance in RBRC01872
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015056
• cachexia in RBRC01872
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015053
• abnormal intestinal epithelium morphology in RBRC01872
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015061
• rectal prolapse in RBRC01872
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015054