Yi-Hsin. Weng, et.al., (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model., Experimental neurology, 2016, 275 Pt 1

http://rdf.ncbi.nlm.nih.gov/pubmed/26363496

Yi-Hsin. Weng, et.al., (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model., Experimental neurology, 2016, 275 Pt 1

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(PDGFB-LRRK2*R1441C)31Hlw
  http://metadb.riken.jp/db/mgi_rdf/MGI:5800408

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal synaptic dopamine release_Tg(PDGFB-LRRK2*R1441C)31Hlw/0
  http://metadb.riken.jp/0010149FVBNTgPDGFBLRRK2R1441C31HlwTgPDGFBLRRK2R1441C31Hlw0TgPDGFBLRRK2R1441C31Hlw
• decreased vertical activity_Tg(PDGFB-LRRK2*R1441C)31Hlw/0
  http://metadb.riken.jp/0002757FVBNTgPDGFBLRRK2R1441C31HlwTgPDGFBLRRK2R1441C31Hlw0TgPDGFBLRRK2R1441C31Hlw
• bradykinesia_Tg(PDGFB-LRRK2*R1441C)31Hlw/0
  http://metadb.riken.jp/0005156FVBNTgPDGFBLRRK2R1441C31HlwTgPDGFBLRRK2R1441C31Hlw0TgPDGFBLRRK2R1441C31Hlw
• loss of dopaminergic neurons_Tg(PDGFB-LRRK2*R1441C)31Hlw/0
  http://metadb.riken.jp/0003244FVBNTgPDGFBLRRK2R1441C31HlwTgPDGFBLRRK2R1441C31Hlw0TgPDGFBLRRK2R1441C31Hlw
• abnormal synaptic bouton morphology_Tg(PDGFB-LRRK2*R1441C)31Hlw/0
  http://metadb.riken.jp/0008571FVBNTgPDGFBLRRK2R1441C31HlwTgPDGFBLRRK2R1441C31Hlw0TgPDGFBLRRK2R1441C31Hlw

class

http://purl.org/net/cito/citesAsAuthority

• Tg(PDGFB-LRRK2*R1441C)31Hlw
  http://metadb.riken.jp/db/mgi_rdf/MGI:5800408