Mourad. Ferdaoussi, et.al., Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells., The Journal of clinical investigation, 2015, 125

http://rdf.ncbi.nlm.nih.gov/pubmed/26389676

Mourad. Ferdaoussi, et.al., Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells., The Journal of clinical investigation, 2015, 125

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Senp1<tm1.1Eyeh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5882691

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• impaired ability to fire action potentials_Senp1<tm1.1Eyeh>/Senp1<tm1.1Eyeh>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0002578IC57BL6Senp1tm11EyehSenp1tm11EyehTgPdx1cre6Tuv0TgPdx1cre6TuvSenp1tm11Eyeh
• abnormal pancreatic beta cell physiology_Senp1<tm1.1Eyeh>/Senp1<tm1.1Eyeh>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0003562IC57BL6Senp1tm11EyehSenp1tm11EyehTgPdx1cre6Tuv0TgPdx1cre6TuvSenp1tm11Eyeh
• decreased circulating insulin level_Senp1<tm1.1Eyeh>/Senp1<tm1.1Eyeh>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0002727IC57BL6Senp1tm11EyehSenp1tm11EyehTgPdx1cre6Tuv0TgPdx1cre6TuvSenp1tm11Eyeh
• decreased insulin secretion_Senp1<tm1.1Eyeh>/Senp1<tm1.1Eyeh>
  http://metadb.riken.jp/0003059NSSenp1tm11EyehSenp1tm11EyehSenp1tm11Eyeh
• impaired glucose tolerance_Senp1<tm1.1Eyeh>/Senp1<tm1.1Eyeh>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0005293IC57BL6Senp1tm11EyehSenp1tm11EyehTgPdx1cre6Tuv0TgPdx1cre6TuvSenp1tm11Eyeh
• impaired glucose tolerance_Senp1<tm1.1Eyeh>/Senp1<tm1.1Eyeh>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0005293IC57BL6Senp1tm11EyehSenp1tm11EyehTgPdx1creEsr1Dam0Senp1tm11EyehTgPdx1creEsr1Dam
• decreased insulin secretion_Senp1<tm1.1Eyeh>/Senp1<tm1.1Eyeh>,Tg(Pdx1-cre/Esr1*)#Dam/0
  http://metadb.riken.jp/0003059IC57BL6Senp1tm11EyehSenp1tm11EyehTgPdx1creEsr1Dam0Senp1tm11EyehTgPdx1creEsr1Dam
• impaired glucose tolerance_Senp1<tm1.1Eyeh>/Senp1<+>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0005293IC57BL6Senp1tm11EyehSenp1TgPdx1cre6Tuv0Senp1TgPdx1cre6TuvSenp1tm11Eyeh
• decreased insulin secretion_Senp1<tm1.1Eyeh>/Senp1<tm1.1Eyeh>,Tg(Pdx1-cre)6Tuv/0
  http://metadb.riken.jp/0003059IC57BL6Senp1tm11EyehSenp1tm11EyehTgPdx1cre6Tuv0TgPdx1cre6TuvSenp1tm11Eyeh
• abnormal pancreatic beta cell physiology_Senp1<tm1.1Eyeh>/Senp1<tm1.1Eyeh>
  http://metadb.riken.jp/0003562NSSenp1tm11EyehSenp1tm11EyehSenp1tm11Eyeh

class

http://purl.org/net/cito/citesAsAuthority

• Senp1<tm1.1Eyeh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5882691