Adam K. Walker, et.al., An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice., Human molecular genetics, 2015, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/26476406

Adam K. Walker, et.al., An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice., Human molecular genetics, 2015, 24

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO/Prnp-TARDBP*)2Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792270

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• neuronal cytoplasmic inclusions_Tg(NEFH-tTA)8Vle/0,Tg(tetO/Prnp-TARDBP*)2Vle/0
  http://metadb.riken.jp/0011975IC3HHeJC57BL6JTgNEFHtTA8Vle0TgtetOPrnpTARDBP2Vle0TgNEFHtTA8VleTgtetOPrnpTARDBP2Vle
• astrocytosis_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO/Prnp-TARDBP*)2Vle/0
  http://metadb.riken.jp/0003354IC3HHeJC57BL6JTgCamk2atTA1Mmay0TgtetOPrnpTARDBP2Vle0TgtetOPrnpTARDBP2VleTgCamk2atTA1Mmay
• hippocampal neuron degeneration_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO/Prnp-TARDBP*)2Vle/0
  http://metadb.riken.jp/0000811IC3HHeJC57BL6JTgCamk2atTA1Mmay0TgtetOPrnpTARDBP2Vle0TgtetOPrnpTARDBP2VleTgCamk2atTA1Mmay
• neuronal cytoplasmic inclusions_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO/Prnp-TARDBP*)2Vle/0
  http://metadb.riken.jp/0011975IC3HHeJC57BL6JTgCamk2atTA1Mmay0TgtetOPrnpTARDBP2Vle0TgtetOPrnpTARDBP2VleTgCamk2atTA1Mmay
• loss of hippocampal neurons_Tg(Camk2a-tTA)1Mmay/0,Tg(tetO/Prnp-TARDBP*)2Vle/0
  http://metadb.riken.jp/0003240IC3HHeJC57BL6JTgCamk2atTA1Mmay0TgtetOPrnpTARDBP2Vle0TgtetOPrnpTARDBP2VleTgCamk2atTA1Mmay

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO/Prnp-TARDBP*)2Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792270