Audrey S. Dickey, et.al., PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically., Nature medicine, 2016, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/26642438

Audrey S. Dickey, et.al., PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically., Nature medicine, 2016, 22

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(CAG-Ppard*E411P)#Als
  http://metadb.riken.jp/db/mgi_rdf/MGI:5897172

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased mitochondria size_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011631B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• impaired coordination_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(CAG-Ppard*E411P)#Als/0
  http://metadb.riken.jp/0001405B6JCgRgs9tm1creYqlTgCAGPpardE411PAlsRgs9tm1creYqlRgs9TgCAGPpardE411PAls0TgCAGPpardE411PAlsRgs9Rgs9tm1creYql
• abnormal mitochondrial ATP synthesis coupled electron transport_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0010956B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• abnormal cerebral cortex morphology_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000788B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• neurodegeneration_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(CAG-Ppard*E411P)#Als/0
  http://metadb.riken.jp/0002229B6JCgRgs9tm1creYqlTgCAGPpardE411PAlsRgs9tm1creYqlRgs9TgCAGPpardE411PAls0TgCAGPpardE411PAlsRgs9Rgs9tm1creYql
• neurodegeneration_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002229B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• decreased brain size_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000774B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• kyphosis_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000160B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• decreased exploration in new environment_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001417B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• abnormal medium spiny neuron morphology_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(CAG-Ppard*E411P)#Als/0
  http://metadb.riken.jp/0008462B6JCgRgs9tm1creYqlTgCAGPpardE411PAlsRgs9tm1creYqlRgs9TgCAGPpardE411PAls0TgCAGPpardE411PAlsRgs9Rgs9tm1creYql
• abnormal motor capabilities/coordination/movement_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(CAG-Ppard*E411P)#Als/0
  http://metadb.riken.jp/0002066B6JCgRgs9tm1creYqlTgCAGPpardE411PAlsRgs9tm1creYqlRgs9TgCAGPpardE411PAls0TgCAGPpardE411PAlsRgs9Rgs9tm1creYql
• abnormal basal ganglion morphology_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0006007B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• limb grasping_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001513B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• kyphosis_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(CAG-Ppard*E411P)#Als/0
  http://metadb.riken.jp/0000160B6JCgRgs9tm1creYqlTgCAGPpardE411PAlsRgs9tm1creYqlRgs9TgCAGPpardE411PAls0TgCAGPpardE411PAlsRgs9Rgs9tm1creYql
• decreased neuron number_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008948B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• abnormal response to novel object_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0003461B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• decreased grip strength_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(CAG-Ppard*E411P)#Als/0
  http://metadb.riken.jp/0010053B6JCgRgs9tm1creYqlTgCAGPpardE411PAlsRgs9tm1creYqlRgs9TgCAGPpardE411PAls0TgCAGPpardE411PAlsRgs9Rgs9tm1creYql
• abnormal motor capabilities/coordination/movement_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002066B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• impaired coordination_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001405B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• decreased body weight_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001262B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• short stride length_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001407B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• decreased dopaminergic neuron number_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011448B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• decreased grip strength_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0010053B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• gliosis_Tg(CAG-Ppard*E411P)#Als/0,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002183B6JCgTgNescre1KlnTgCAGPpardE411PAlsTgCAGPpardE411PAls0TgNescre1Kln0TgCAGPpardE411PAlsTgNescre1Kln
• limb grasping_Rgs9<tm1(cre)Yql>/Rgs9<+>,Tg(CAG-Ppard*E411P)#Als/0
  http://metadb.riken.jp/0001513B6JCgRgs9tm1creYqlTgCAGPpardE411PAlsRgs9tm1creYqlRgs9TgCAGPpardE411PAls0TgCAGPpardE411PAlsRgs9Rgs9tm1creYql

class

http://purl.org/net/cito/citesAsAuthority

• Tg(CAG-Ppard*E411P)#Als
  http://metadb.riken.jp/db/mgi_rdf/MGI:5897172