Yuan. Mei, et.al., Adult restoration of Shank3 expression rescues selective autistic-like phenotypes., Nature, 2016, 530

http://rdf.ncbi.nlm.nih.gov/pubmed/26886798

Yuan. Mei, et.al., Adult restoration of Shank3 expression rescues selective autistic-like phenotypes., Nature, 2016, 530

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Shank3<tm5.1Gfng>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5775650

class

http://purl.org/net/cito/citesAsAuthority

• Shank3<tm5.1Gfng>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5775650

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased anxiety-related response_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0001363I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe
• impaired coordination_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0001405I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe
• decreased excitatory postsynaptic current amplitude_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>
  http://metadb.riken.jp/0011270I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngShank3tm51Gfng
• decreased exploration in new environment_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0001417I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe
• decreased body weight_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0001262I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe
• increased grooming behavior_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>
  http://metadb.riken.jp/0001441I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngShank3tm51Gfng
• abnormal miniature excitatory postsynaptic currents_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0004753I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe
• decreased exploration in new environment_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>
  http://metadb.riken.jp/0001417I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngShank3tm51Gfng
• abnormal social investigation_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0001360I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe
• increased anxiety-related response_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>
  http://metadb.riken.jp/0001363I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngShank3tm51Gfng
• decreased excitatory postsynaptic current amplitude_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0011270I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe
• decreased vertical activity_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0002757I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe
• increased grooming behavior_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0001441I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe
• impaired coordination_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>
  http://metadb.riken.jp/0001405I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngShank3tm51Gfng
• abnormal medium spiny neuron morphology_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0008462I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe
• abnormal dendritic spine morphology_Shank3<tm5.1Gfng>/Shank3<tm5.1Gfng>,Tg(CAG-cre/Esr1*)1Lbe/0
  http://metadb.riken.jp/0009936I129S1Sv129S1SvImJ129X1SvJC57BL6JShank3tm51GfngShank3tm51GfngTgCAGcreEsr11Lbe0Shank3tm51GfngTgCAGcreEsr11Lbe