Chunxing. Yang, et.al., Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity., Proceedings of the National Academy of Sciences of the United States of America, 2016, 113

http://rdf.ncbi.nlm.nih.gov/pubmed/27681617

Chunxing. Yang, et.al., Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity., Proceedings of the National Academy of Sciences of the United States of America, 2016, 113

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-PFN1)34Zxu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796265
• Tg(Prnp-PFN1*C71G)22Zxu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796267
• Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796269

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• progressive muscle weakness_Tg(Prnp-PFN1*C71G)22Zxu/0
  http://metadb.riken.jp/0000748IFVBNTgPrnpPFN1C71G22Zxu0TgPrnpPFN1C71G22Zxu
• progressive muscle weakness_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/0
  http://metadb.riken.jp/0000748IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67Zxu0TgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22Zxu
• progressive muscle weakness_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0000748IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• progressive muscle weakness_Tg(Thy1-PFN1*C71G)67Zxu/0
  http://metadb.riken.jp/0000748NSTgThy1PFN1C71G67Zxu0TgThy1PFN1C71G67Zxu
• progressive muscle weakness_Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0000748NSTgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgThy1PFN1C71G67Zxu
• paralysis_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/0
  http://metadb.riken.jp/0000753IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67Zxu0TgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22Zxu
他23件を見る
• paralysis_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0000753IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• paralysis_Tg(Thy1-PFN1*C71G)67Zxu/0
  http://metadb.riken.jp/0000753NSTgThy1PFN1C71G67Zxu0TgThy1PFN1C71G67Zxu
• paralysis_Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0000753NSTgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgThy1PFN1C71G67Zxu
• abnormal motor neuron morphology_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0000937IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• motor neuron degeneration_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0000938IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• decreased motor neuron number_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0000939IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• abnormal motor neuron innervation pattern_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0000940IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• decreased body weight_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0001262IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• prenatal lethality_Tg(Prnp-PFN1*C71G)22Zxu/Tg(Prnp-PFN1*C71G)22Zxu
  http://metadb.riken.jp/0002080IFVBNTgPrnpPFN1C71G22ZxuTgPrnpPFN1C71G22ZxuTgPrnpPFN1C71G22Zxu
• premature death_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/0
  http://metadb.riken.jp/0002083IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67Zxu0TgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22Zxu
• premature death_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0002083IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• premature death_Tg(Thy1-PFN1*C71G)67Zxu/0
  http://metadb.riken.jp/0002083NSTgThy1PFN1C71G67Zxu0TgThy1PFN1C71G67Zxu
• premature death_Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0002083NSTgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgThy1PFN1C71G67Zxu
• neurodegeneration_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0002229IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• decreased vertical activity_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0002757IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• astrocytosis_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0003354IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• axon degeneration_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0005405IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• microgliosis_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0008918IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• increased variability of skeletal muscle fiber size_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0009403IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• skeletal muscle fiber atrophy_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0009413IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• decreased grip strength_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0010053IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• neuronal cytoplasmic inclusions_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0011975IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu
• abnormal cell cytoskeleton morphology_Tg(Prnp-PFN1*C71G)22Zxu/0,Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/0020378IFVBNTgPrnpPFN1C71G22Zxu0TgThy1PFN1C71G67ZxuTgThy1PFN1C71G67ZxuTgPrnpPFN1C71G22ZxuTgThy1PFN1C71G67Zxu

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-PFN1)34Zxu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796265
• Tg(Prnp-PFN1*C71G)22Zxu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796267
• Tg(Thy1-PFN1*C71G)67Zxu
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796269