Toshifumi. Fujiwara, et.al., PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis., JCI insight, 2016, 1

http://rdf.ncbi.nlm.nih.gov/pubmed/27777970

Toshifumi. Fujiwara, et.al., PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis., JCI insight, 2016, 1

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5888869
• Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5806231

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal osteoclast morphology_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0004982IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• decreased bone ossification_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0020040I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• decreased bone trabecular spacing_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0013631I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• increased trabecular bone mass_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0010872IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• abnormal osteoclast morphology_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0004982I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• increased trabecular bone volume_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0010878I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• abnormal osteoclast physiology_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0001541I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• decreased bone resorption_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0004993IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• decreased lysosomal enzyme secretion_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0003173IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• increased bone trabecula number_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0010868I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• increased trabecular bone volume_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0010878IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• abnormal lysosome morphology_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0005058IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• decreased bone ossification_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0020040IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• increased trabecular bone mass_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0010872I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• decreased bone mineralization_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0020137IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• abnormal lysosome morphology_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0005058I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• decreased osteoblast cell number_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0004989I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• increased bone trabecula number_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0010868IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• decreased lysosomal enzyme secretion_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0003173I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• abnormal osteoclast physiology_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0001541IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• decreased bone trabecular spacing_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0013631IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• decreased osteoblast cell number_Ctsk<tm1(cre)Ska>/Ctsk<+>,Plekhm1<tm1.1Hzhao>/Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/0004989IC57BL6JC57BL6NCrljCBAJNCrljCtsktm1creSkaCtskPlekhm1tm11HzhaoPlekhm1tm11HzhaoCtskCtsktm1creSkaPlekhm1tm11Hzhao
• decreased bone resorption_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0004993I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao
• decreased bone mineralization_Plekhm1<tm1.2Hzhao>/Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/0020137I129S1SvC57BL6JPlekhm1tm12HzhaoPlekhm1tm12HzhaoPlekhm1tm12Hzhao

class

http://purl.org/net/cito/citesAsAuthority

• Plekhm1<tm1.2Hzhao>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5888869
• Plekhm1<tm1.1Hzhao>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5806231