Guo. Zhu, et.al., PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation., Cancer research, 2017, 77

http://rdf.ncbi.nlm.nih.gov/pubmed/27815386

Guo. Zhu, et.al., PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation., Cancer research, 2017, 77

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal nervous system physiology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0003633I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• abnormal cerebellum morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0000849I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• abnormal cerebellum morphology_Pten<tm2Mak>/Pten<tm2Mak>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0000849I129P2OlaHsdPtentm2MakPtentm2MakTrp53tm1BrnTrp53tm1BrnTgNescreERT2ALPP1Sbk0Ptentm2MakTrp53tm1BrnTgNescreERT2ALPP1Sbk
• abnormal cerebellar Purkinje cell layer_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0000875I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• seizures_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0002064I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• increased tumor incidence_Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0002020I129P2OlaHsdTrp53tm1BrnTrp53tm1BrnTgNescreERT2ALPP1Sbk0TgNescreERT2ALPP1SbkTrp53tm1Brn
• ataxia_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0001393I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• premature death_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0002083I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• increased brain size_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0005238I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• abnormal cerebellar molecular layer_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0000889I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• ectopic cerebellar granule cells_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0002762I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• lethargy_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0005202I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• hydroencephaly_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0001891I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• abnormal cerebellar granule cell morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0004098I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• thin cerebellar granule layer_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0006099I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• increased medulloblastoma incidence_Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0006283I129P2OlaHsdTrp53tm1BrnTrp53tm1BrnTgNescreERT2ALPP1Sbk0TgNescreERT2ALPP1SbkTrp53tm1Brn
• increased medulloblastoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0006283I129P2OlaHsdPtentm2MakPtentm2MakTrp53tm1BrnTrp53tm1BrnTgNescreERT2ALPP1Sbk0Ptentm2MakTrp53tm1BrnTgNescreERT2ALPP1Sbk
• increased brain tumor incidence_Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0009277I129P2OlaHsdTrp53tm1BrnTrp53tm1BrnTgNescreERT2ALPP1Sbk0TgNescreERT2ALPP1SbkTrp53tm1Brn
• megacephaly_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0000434I129P2OlaHsdPtentm2MakPtentm2MakTgNescreERT2ALPP1Sbk0Ptentm2MakTgNescreERT2ALPP1Sbk
• increased glioma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
  http://metadb.riken.jp/0010278I129P2OlaHsdPtentm2MakPtentm2MakTrp53tm1BrnTrp53tm1BrnTgNescreERT2ALPP1Sbk0Ptentm2MakTrp53tm1BrnTgNescreERT2ALPP1Sbk

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cerebellar Purkinje cell layer in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020371
• neoplasm in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020375
• thin cerebellar granule layer in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020373
• abnormal nervous system physiology in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020374
• ectopic cerebellar granule cells in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020372