Daniel B. Graham, et.al., TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation., Cell reports, 2016, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/27974209

Daniel B. Graham, et.al., TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation., Cell reports, 2016, 17

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tmem258<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5892142

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• embryonic lethality, complete penetrance_Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/0011092IC57BL6NTacTmem258tm11KOMPVlcgTmem258tm11KOMPVlcgTmem258tm11KOMPVlcg
• increased susceptibility to colitis induced morbidity/mortality_Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<+>
  http://metadb.riken.jp/0013298IC57BL6NTacTmem258tm11KOMPVlcgTmem258Tmem258tm11KOMPVlcgTmem258
• increased cell death_Gt(ROSA)26Sor<tm1(CAG-cas9*,-EGFP)Fezh>/?,Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<+>
  http://metadb.riken.jp/0012556IC57BL6NTacGtROSA26Sortm1CAGcas9EGFPFezhTmem258tm11KOMPVlcgTmem258Tmem258tm11KOMPVlcgTmem258GtROSA26Sortm1CAGcas9EGFPFezh
• abnormal enterocyte proliferation_Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<+>
  http://metadb.riken.jp/0008883IC57BL6NTacTmem258tm11KOMPVlcgTmem258Tmem258tm11KOMPVlcgTmem258
• increased enterocyte apoptosis_Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<+>
  http://metadb.riken.jp/0008885IC57BL6NTacTmem258tm11KOMPVlcgTmem258Tmem258tm11KOMPVlcgTmem258
• increased endoplasmic reticulum stress_Gt(ROSA)26Sor<tm1(CAG-cas9*,-EGFP)Fezh>/?,Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<+>
  http://metadb.riken.jp/0020354IC57BL6NTacGtROSA26Sortm1CAGcas9EGFPFezhTmem258tm11KOMPVlcgTmem258Tmem258tm11KOMPVlcgTmem258GtROSA26Sortm1CAGcas9EGFPFezh
• increased susceptibility to induced colitis_Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<+>
  http://metadb.riken.jp/0008537IC57BL6NTacTmem258tm11KOMPVlcgTmem258Tmem258tm11KOMPVlcgTmem258
• increased endoplasmic reticulum stress_Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<+>
  http://metadb.riken.jp/0020354IC57BL6NTacTmem258tm11KOMPVlcgTmem258Tmem258tm11KOMPVlcgTmem258
• abnormal large intestine crypts of Lieberkuhn morphology_Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<+>
  http://metadb.riken.jp/0004842IC57BL6NTacTmem258tm11KOMPVlcgTmem258Tmem258tm11KOMPVlcgTmem258
• decreased colon length_Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<+>
  http://metadb.riken.jp/0013956IC57BL6NTacTmem258tm11KOMPVlcgTmem258Tmem258tm11KOMPVlcgTmem258
• increased susceptibility to weight loss_Tmem258<tm1.1(KOMP)Vlcg>/Tmem258<+>
  http://metadb.riken.jp/0010180IC57BL6NTacTmem258tm11KOMPVlcgTmem258Tmem258tm11KOMPVlcgTmem258

class

http://purl.org/net/cito/citesAsAuthority

• Tmem258<tm1.1(KOMP)Vlcg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5892142