D. Moechars, et.al., Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice., The EMBO journal, 1996, 15

http://rdf.ncbi.nlm.nih.gov/pubmed/8635459

D. Moechars, et.al., Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice., The EMBO journal, 1996, 15

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(APP-App*R609D*K612E)7Vln
  http://metadb.riken.jp/db/mgi_rdf/MGI:3720083
• Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/db/mgi_rdf/MGI:3720070
• Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/db/mgi_rdf/MGI:3720071
• Tg(Thy1-App*R609D*K612E)2Vln
  http://metadb.riken.jp/db/mgi_rdf/MGI:3720072

class

http://purl.org/net/cito/citesAsAuthority

• Tg(APP-App*R609D*K612E)7Vln
  http://metadb.riken.jp/db/mgi_rdf/MGI:3720083
• Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/db/mgi_rdf/MGI:3720070
• Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/db/mgi_rdf/MGI:3720071
• Tg(Thy1-App*R609D*K612E)2Vln
  http://metadb.riken.jp/db/mgi_rdf/MGI:3720072

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased thigmotaxis_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0002797IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• abnormal locomotor activation_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0003313IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• abnormal neuron morphology_Tg(Thy1-App*R609D*K612E)2Vln/0
  http://metadb.riken.jp/0002882IC57BLCBAJTgThy1AppR609DK612E2Vln0TgThy1AppR609DK612E2Vln
• behavioral arrest_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0008035IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• abnormal locomotor activation_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0003313IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• increased susceptibility to pharmacologically induced seizures_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0002906IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• premature death_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0002083IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• gliosis_Tg(Thy1-App*R609D*K612E)2Vln/0
  http://metadb.riken.jp/0002183IC57BLCBAJTgThy1AppR609DK612E2Vln0TgThy1AppR609DK612E2Vln
• abnormal respiration_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0001943IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• abnormal locomotor activation_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0003313IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• abnormal response to new environment_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0001413IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• abnormal respiration_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0001943IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• decreased susceptibility to pharmacologically induced seizures_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0002887IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• abnormal response to new environment_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0001413IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• lethargy_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0005202IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• myoclonus_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0000243IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• abnormal microglial cell morphology_Tg(Thy1-App*R609D*K612E)2Vln/0
  http://metadb.riken.jp/0000136IC57BLCBAJTgThy1AppR609DK612E2Vln0TgThy1AppR609DK612E2Vln
• abnormal microglial cell morphology_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0000136IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• lethargy_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0005202IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• increased thigmotaxis_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0002797IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• seizures_Tg(Thy1-App*R609D*K612E)2Vln/0
  http://metadb.riken.jp/0002064IC57BLCBAJTgThy1AppR609DK612E2Vln0TgThy1AppR609DK612E2Vln
• premature death_Tg(Thy1-App*R609D*K612E)2Vln/0
  http://metadb.riken.jp/0002083IC57BLCBAJTgThy1AppR609DK612E2Vln0TgThy1AppR609DK612E2Vln
• seizures_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0002064IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• increased thigmotaxis_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0002797IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• myoclonus_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0000243IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• tonic-clonic seizures_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0003997IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• neuron degeneration_Tg(APP-App*R609D*K612E)7Vln/0
  http://metadb.riken.jp/0003224IFVBTgAPPAppR609DK612E7Vln0TgAPPAppR609DK612E7Vln
• seizures_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0002064IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• tonic-clonic seizures_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0003997IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• neuron degeneration_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0003224IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• tonic-clonic seizures_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0003997IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• increased thigmotaxis_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0002797IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• abnormal neuron morphology_Tg(APP-App*R609D*K612E)7Vln/0
  http://metadb.riken.jp/0002882IFVBTgAPPAppR609DK612E7Vln0TgAPPAppR609DK612E7Vln
• abnormal respiration_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0001943IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• increased aggression towards mice_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0001353IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• abnormal neuron morphology_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0002882IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• abnormal response to new environment_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0001413IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• increased aggression towards mice_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0001353IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• behavioral arrest_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0008035IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• neuron degeneration_Tg(Thy1-App*R609D*K612E)2Vln/0
  http://metadb.riken.jp/0003224IC57BLCBAJTgThy1AppR609DK612E2Vln0TgThy1AppR609DK612E2Vln
• abnormal astrocyte morphology_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0002182IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• clonic seizures_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0003996IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• astrocytosis_Tg(Thy1-App*R609D*K612E)2Vln/0
  http://metadb.riken.jp/0003354IC57BLCBAJTgThy1AppR609DK612E2Vln0TgThy1AppR609DK612E2Vln
• gliosis_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0002183IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• myoclonus_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0000243IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• abnormal response to new environment_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0001413IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• clonic seizures_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0003996IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• gliosis_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0002183IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• neuron degeneration_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0003224IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• decreased susceptibility to pharmacologically induced seizures_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0002887IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• behavioral arrest_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0008035IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• abnormal respiration_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0001943IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• abnormal astrocyte morphology_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0002182IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• astrocytosis_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0003354IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• abnormal neuron morphology_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0002882IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• premature death_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0002083IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• increased neuron apoptosis_Tg(APP-App*R609D*K612E)7Vln/0
  http://metadb.riken.jp/0003203IFVBTgAPPAppR609DK612E7Vln0TgAPPAppR609DK612E7Vln
• tonic-clonic seizures_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0003997IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• seizures_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0002064IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• premature death_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0002083IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• increased neuron apoptosis_Tg(Thy1-App*R609D*K612E)2Vln/0
  http://metadb.riken.jp/0003203IC57BLCBAJTgThy1AppR609DK612E2Vln0TgThy1AppR609DK612E2Vln
• lethargy_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0005202IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• abnormal locomotor activation_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0003313IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• seizures_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0002064IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• premature death_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0002083IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• myoclonus_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0000243IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• increased neuron apoptosis_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0003203IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• clonic seizures_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0003996IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• abnormal microglial cell morphology_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0000136IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• astrocytosis_Tg(Thy1-App*R609D*K612E)4Vln/0
  http://metadb.riken.jp/0003354IFVBTgThy1AppR609DK612E4Vln0TgThy1AppR609DK612E4Vln
• behavioral arrest_Tg(Thy1-App*R609D*K612E)6Vln/0
  http://metadb.riken.jp/0008035IFVBTgThy1AppR609DK612E6Vln0TgThy1AppR609DK612E6Vln
• increased susceptibility to pharmacologically induced seizures_Tg(Thy1-App*R609D*K612E)6Vln/Tg(Thy1-App*R609D*K612E)6Vln
  http://metadb.riken.jp/0002906IFVBTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6VlnTgThy1AppR609DK612E6Vln
• clonic seizures_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0003996IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln
• lethargy_Tg(Thy1-App*R609D*K612E)4Vln/Tg(Thy1-App*R609D*K612E)4Vln
  http://metadb.riken.jp/0005202IFVBTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4VlnTgThy1AppR609DK612E4Vln