J. Eggenschwiler, et.al., Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes., Genes & development, 1997, 11

http://rdf.ncbi.nlm.nih.gov/pubmed/9389646

J. Eggenschwiler, et.al., Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes., Genes & development, 1997, 11

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• cleft palate_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0000111I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• abnormal sternum morphology_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0000157I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• abnormal xiphoid process morphology_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0000159I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• abnormal heart morphology_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0000266I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• polydactyly_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>,Igf2r<tm1Stw>/Igf2r<+>
  http://metadb.riken.jp/0000562I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Igf2rtm1StwIgf2rIgf2tm1RobRr27Igf2rtm1StwRr27tm1TilgIgf2Igf2r
• polydactyly_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0000562I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
他45件を見る
• polydactyly_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0000562I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• abnormal lens morphology_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0001303I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• edema_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0001785I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• pericardial edema_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0001787I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• increased heart weight_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0002833I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• increased heart weight_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0002833I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• increased liver weight_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0002981I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• increased liver weight_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0002981I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• abnormal lumbar vertebrae morphology_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003049I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• abnormal lumbar vertebrae morphology_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003049I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• omphalocele_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003052I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• omphalocele_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003052I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• abnormal lens epithelium morphology_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003237I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• abnormal fetal cardiomyocyte proliferation_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003567I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• abnormal fetal cardiomyocyte proliferation_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003567I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• increased hepatocyte proliferation_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003893I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• increased hepatocyte proliferation_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003893I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• decreased kidney weight_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003918I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• decreased kidney weight_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0003918I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• split sternum_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0004320I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• increased placenta weight_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0004920I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• increased placenta weight_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0004920I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• abnormal heart ventricle morphology_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0005294I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• abnormal heart ventricle morphology_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0005294I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• abnormal myocardium layer morphology_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0005329I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• abnormal circulating hormone level_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0005418I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• abnormal circulating hormone level_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0005418I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• abnormal lens development_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0005545I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• abnormal heart septum morphology_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0006113I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• abnormal heart septum morphology_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0006113I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• delayed eyelid fusion_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0009265I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• delayed eyelid fusion_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0009265I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• increased fetal weight_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>,Igf2r<tm1Stw>/Igf2r<+>
  http://metadb.riken.jp/0009432I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Igf2rtm1StwIgf2rIgf2tm1RobRr27Igf2rtm1StwRr27tm1TilgIgf2Igf2r
• increased fetal weight_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0009432I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• increased fetal weight_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0009432I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• enlarged aortic valve_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0010591I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• thick aortic valve_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0010594I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• enlarged pulmonary valve_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0010600I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• thick pulmonary valve_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0010601I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• postnatal lethality, complete penetrance_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0011085I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• neonatal lethality, complete penetrance_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>,Igf2r<tm1Stw>/Igf2r<+>
  http://metadb.riken.jp/0011087I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Igf2rtm1StwIgf2rIgf2tm1RobRr27Igf2rtm1StwRr27tm1TilgIgf2Igf2r
• lethality throughout fetal growth and development, complete penetrance_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0011099I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• lethality throughout fetal growth and development, incomplete penetrance_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0011109I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2
• adrenal gland cyst_Rr27<tm1Tilg>/Rr27<+>,Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0013309I129SSvEv129S1SvC57BL6JRr27tm1TilgRr27Igf2tm1RobIgf2Rr27Igf2tm1RobRr27tm1TilgIgf2
• adrenal gland cyst_Igf2<tm1Rob>/Igf2<+>
  http://metadb.riken.jp/0013309I129SSvEvC57BL6JIgf2tm1RobIgf2Igf2tm1RobIgf2