S. Guerder, et.al., Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes., Journal of immunology (Baltimore, Md. : 1950), 1998, 161

http://rdf.ncbi.nlm.nih.gov/pubmed/9725204

S. Guerder, et.al., Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes., Journal of immunology (Baltimore, Md. : 1950), 1998, 161

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Ins2-CD86)12B70Flv
  http://metadb.riken.jp/db/mgi_rdf/MGI:3764558

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• insulitis_Tg(Ins2-CD80)3B7Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0004031IC57BL6CBACaSJLTgIns2CD803B7Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2H2EadIns2H2Eb1b1877BriTgIns2CD803B7Flv
• increased circulating glucose level_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0005559IC57BL6CBACaSJLTgIns2CD8612B70Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2CD8612B70FlvTgIns2H2EadIns2H2Eb1b1877Bri
• decreased pancreatic beta cell number_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0003339IC57BL6CBACaSJLTgIns2CD8612B70Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2CD8612B70FlvTgIns2H2EadIns2H2Eb1b1877Bri
• increased CD4-positive, alpha beta T cell number_Tg(Ins2-Tnf)17Flv/0
  http://metadb.riken.jp/0008074IC57BL6TgIns2Tnf17Flv0TgIns2Tnf17Flv
• abnormal cytokine secretion_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0003009IC57BL6CBACaSJLTgIns2CD8612B70Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2CD8612B70FlvTgIns2H2EadIns2H2Eb1b1877Bri
• dehydration_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0001429IC57BL6CBACaSJLTgIns2CD8612B70Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2CD8612B70FlvTgIns2H2EadIns2H2Eb1b1877Bri
• weight loss_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0001263IC57BL6CBACaSJLTgIns2CD8612B70Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2CD8612B70FlvTgIns2H2EadIns2H2Eb1b1877Bri
• increased susceptibility to autoimmune diabetes_Tg(Ins2-CD80)3B7Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0004803IC57BL6CBACaSJLTgIns2CD803B7Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2H2EadIns2H2Eb1b1877BriTgIns2CD803B7Flv
• abnormal cytokine secretion_Tg(Ins2-CD86)12B70Flv/0
  http://metadb.riken.jp/0003009IC57BL6CBACaTgIns2CD8612B70Flv0TgIns2CD8612B70Flv
• decreased susceptibility to autoimmune diabetes_Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0004804IC57BL6SJLTgIns2H2EadIns2H2Eb1b1877Bri0TgIns2H2EadIns2H2Eb1b1877Bri
• decreased CD8-positive, alpha-beta T cell number_Tg(Ins2-Tnf)17Flv/0
  http://metadb.riken.jp/0008079IC57BL6TgIns2Tnf17Flv0TgIns2Tnf17Flv
• decreased susceptibility to autoimmune diabetes_Tg(Ins2-CD86)12B70Flv/0
  http://metadb.riken.jp/0004804IC57BL6CBACaTgIns2CD8612B70Flv0TgIns2CD8612B70Flv
• dehydration_Tg(Ins2-CD80)3B7Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0001429IC57BL6CBACaSJLTgIns2CD803B7Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2H2EadIns2H2Eb1b1877BriTgIns2CD803B7Flv
• increased susceptibility to autoimmune diabetes_Tg(Ins2-CD80)3B7Flv/0,Tg(Ins2-Tnf)17Flv/0
  http://metadb.riken.jp/0004803IC57BL6CBACaTgIns2CD803B7Flv0TgIns2Tnf17Flv0TgIns2Tnf17FlvTgIns2CD803B7Flv
• increased circulating glucose level_Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0005559IC57BL6SJLTgIns2H2EadIns2H2Eb1b1877Bri0TgIns2H2EadIns2H2Eb1b1877Bri
• abnormal cytokine secretion_Tg(Ins2-CD80)3B7Flv/0,Tg(Ins2-Tnf)17Flv/0
  http://metadb.riken.jp/0003009IC57BL6CBACaTgIns2CD803B7Flv0TgIns2Tnf17Flv0TgIns2Tnf17FlvTgIns2CD803B7Flv
• abnormal cytokine secretion_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-Tnf)17Flv/0
  http://metadb.riken.jp/0003009IC57BL6CBACaTgIns2CD8612B70Flv0TgIns2Tnf17Flv0TgIns2CD8612B70FlvTgIns2Tnf17Flv
• increased susceptibility to autoimmune diabetes_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0004803IC57BL6CBACaSJLTgIns2CD8612B70Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2CD8612B70FlvTgIns2H2EadIns2H2Eb1b1877Bri
• abnormal pancreatic islet morphology_Tg(Ins2-CD80)3B7Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0005215IC57BL6CBACaSJLTgIns2CD803B7Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2H2EadIns2H2Eb1b1877BriTgIns2CD803B7Flv
• increased susceptibility to autoimmune diabetes_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-Tnf)17Flv/0
  http://metadb.riken.jp/0004803IC57BL6CBACaTgIns2CD8612B70Flv0TgIns2Tnf17Flv0TgIns2CD8612B70FlvTgIns2Tnf17Flv
• insulitis_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0004031IC57BL6CBACaSJLTgIns2CD8612B70Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2CD8612B70FlvTgIns2H2EadIns2H2Eb1b1877Bri
• increased circulating glucose level_Tg(Ins2-CD80)3B7Flv/0,Tg(Ins2-Tnf)17Flv/0
  http://metadb.riken.jp/0005559IC57BL6CBACaTgIns2CD803B7Flv0TgIns2Tnf17Flv0TgIns2Tnf17FlvTgIns2CD803B7Flv
• premature death_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0002083IC57BL6CBACaSJLTgIns2CD8612B70Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2CD8612B70FlvTgIns2H2EadIns2H2Eb1b1877Bri
• weight loss_Tg(Ins2-CD80)3B7Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0001263IC57BL6CBACaSJLTgIns2CD803B7Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2H2EadIns2H2Eb1b1877BriTgIns2CD803B7Flv
• periinsulitis_Tg(Ins2-CD86)12B70Flv/0
  http://metadb.riken.jp/0005580IC57BL6CBACaTgIns2CD8612B70Flv0TgIns2CD8612B70Flv
• increased circulating glucose level_Tg(Ins2-CD86)12B70Flv/0,Tg(Ins2-Tnf)17Flv/0
  http://metadb.riken.jp/0005559IC57BL6CBACaTgIns2CD8612B70Flv0TgIns2Tnf17Flv0TgIns2CD8612B70FlvTgIns2Tnf17Flv
• premature death_Tg(Ins2-CD80)3B7Flv/0,Tg(Ins2-H2-Ea<d>,Ins2-H2-Eb1<b>)187-7Bri/0
  http://metadb.riken.jp/0002083IC57BL6CBACaSJLTgIns2CD803B7Flv0TgIns2H2EadIns2H2Eb1b1877Bri0TgIns2H2EadIns2H2Eb1b1877BriTgIns2CD803B7Flv

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Ins2-CD86)12B70Flv
  http://metadb.riken.jp/db/mgi_rdf/MGI:3764558