C. Postic, et.al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase., The Journal of biological chemistry, 1999, 274

http://rdf.ncbi.nlm.nih.gov/pubmed/9867845

C. Postic, et.al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase., The Journal of biological chemistry, 1999, 274

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gck<tm1.1Mgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177709
• Gck<tm1Mgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177708
• Gck<tm1.2Mgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177710
• Tg(Ins2-cre)25Mgn
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176227
• Tg(Alb-cre)21Mgn
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176228

class

http://purl.org/net/cito/citesAsAuthority

• Gck<tm1.1Mgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177709
• Gck<tm1Mgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177708
• Gck<tm1.2Mgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177710
• Tg(Ins2-cre)25Mgn
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176227
• Tg(Alb-cre)21Mgn
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176228

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hyperglycemia_Gck<tm1.1Mgn>/Gck<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001559I129S6SvEvTacC57BL6DBA2Gcktm11MgnGckTgIns2cre25Mgn0GckTgIns2cre25MgnGcktm11Mgn
• decreased circulating insulin level_Gck<tm1.2Mgn>/Gck<tm1.2Mgn>
  http://metadb.riken.jp/0002727I129S6SvEvTacC57BL6Gcktm12MgnGcktm12MgnGcktm12Mgn
• increased circulating glucose level_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005559I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgAlbcre21Mgn0Gcktm11MgnTgAlbcre21Mgn
• postnatal lethality, complete penetrance_Gck<tm1.2Mgn>/Gck<tm1.2Mgn>
  http://metadb.riken.jp/0011085I129S6SvEvTacC57BL6Gcktm12MgnGcktm12MgnGcktm12Mgn
• hyperglycemia_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001559I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgIns2cre25Mgn0Gcktm11MgnTgIns2cre25Mgn
• decreased glycogen level_Gck<tm1.2Mgn>/Gck<tm1.2Mgn>
  http://metadb.riken.jp/0005439I129S6SvEvTacC57BL6Gcktm12MgnGcktm12MgnGcktm12Mgn
• impaired glucose tolerance_Gck<tm1.1Mgn>/Gck<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005293I129S6SvEvTacC57BL6DBA2Gcktm11MgnGckTgIns2cre25Mgn0GckTgIns2cre25MgnGcktm11Mgn
• decreased circulating insulin level_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0002727I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgIns2cre25Mgn0Gcktm11MgnTgIns2cre25Mgn
• neonatal lethality, incomplete penetrance_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0011088I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgIns2cre25Mgn0Gcktm11MgnTgIns2cre25Mgn
• insulin resistance_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005331I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgAlbcre21Mgn0Gcktm11MgnTgAlbcre21Mgn
• decreased insulin secretion_Gck<tm1.1Mgn>/Gck<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0003059I129S6SvEvTacC57BL6DBA2Gcktm11MgnGckTgIns2cre25Mgn0GckTgIns2cre25MgnGcktm11Mgn
• hyperglycemia_Gck<tm1.2Mgn>/Gck<+>
  http://metadb.riken.jp/0001559I129S6SvEvTacC57BL6Gcktm12MgnGckGckGcktm12Mgn
• decreased glycogen level_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005439I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgIns2cre25Mgn0Gcktm11MgnTgIns2cre25Mgn
• hyperglycemia_Gck<tm1.2Mgn>/Gck<tm1.2Mgn>
  http://metadb.riken.jp/0001559I129S6SvEvTacC57BL6Gcktm12MgnGcktm12MgnGcktm12Mgn
• increased circulating glucose level_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>
  http://metadb.riken.jp/0005559I129S6SvEvTacC57BL6Gcktm11MgnGcktm11MgnGcktm11Mgn
• hepatic steatosis_Gck<tm1.2Mgn>/Gck<tm1.2Mgn>
  http://metadb.riken.jp/0002628I129S6SvEvTacC57BL6Gcktm12MgnGcktm12MgnGcktm12Mgn
• decreased glycogen level_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005439I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgAlbcre21Mgn0Gcktm11MgnTgAlbcre21Mgn
• decreased insulin secretion_Gck<tm1.2Mgn>/Gck<+>
  http://metadb.riken.jp/0003059I129S6SvEvTacC57BL6Gcktm12MgnGckGckGcktm12Mgn
• abnormal glucose homeostasis_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002078I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgAlbcre21Mgn0Gcktm11MgnTgAlbcre21Mgn
• impaired glucose tolerance_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005293I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgAlbcre21Mgn0Gcktm11MgnTgAlbcre21Mgn
• increased circulating insulin level_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002079I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgAlbcre21Mgn0Gcktm11MgnTgAlbcre21Mgn
• hepatic steatosis_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0002628I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgIns2cre25Mgn0Gcktm11MgnTgIns2cre25Mgn
• decreased insulin secretion_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003059I129S6SvEvTacC57BL6DBA2Gcktm11MgnGcktm11MgnTgAlbcre21Mgn0Gcktm11MgnTgAlbcre21Mgn
• increased circulating glucose level_Gck<tm1.1Mgn>/Gck<tm1.1Mgn>
  http://metadb.riken.jp/0005559129S6SvEvTacGcktm11MgnGcktm11MgnGcktm11MgnGcktm11Mgn
• hepatic steatosis_Gck<tm1.2Mgn>/Gck<+>
  http://metadb.riken.jp/0002628I129S6SvEvTacC57BL6Gcktm12MgnGckGckGcktm12Mgn
• decreased glycogen level_Gck<tm1.2Mgn>/Gck<+>
  http://metadb.riken.jp/0005439I129S6SvEvTacC57BL6Gcktm12MgnGckGckGcktm12Mgn
• increased circulating free fatty acid level_Gck<tm1.2Mgn>/Gck<tm1.2Mgn>
  http://metadb.riken.jp/0001554I129S6SvEvTacC57BL6Gcktm12MgnGcktm12MgnGcktm12Mgn
• decreased glycogen level_Gck<tm1.1Mgn>/Gck<+>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005439I129S6SvEvTacC57BL6DBA2Gcktm11MgnGckTgIns2cre25Mgn0GckTgIns2cre25MgnGcktm11Mgn
• increased circulating glucose level_Gck<tm1Mgn>/Gck<tm1Mgn>
  http://metadb.riken.jp/0005559I129S6SvEvTacC57BL6Gcktm1MgnGcktm1MgnGcktm1Mgn
• impaired glucose tolerance_Gck<tm1.2Mgn>/Gck<+>
  http://metadb.riken.jp/0005293I129S6SvEvTacC57BL6Gcktm12MgnGckGckGcktm12Mgn