increased urine aldosterone level_Wnk1<tm2.1Juha>/Wnk1<+>,Tg(Pgk1-cre)1Lni/0

http://metadb.riken.jp/0011540I129S2SvPasBALBcC57BL6SJLWnk1tm21JuhaWnk1TgPgk1cre1Lni0Wnk1tm21JuhaWnk1TgPgk1cre1Lni

increased urine aldosterone level_Wnk1<tm2.1Juha>/Wnk1<+>,Tg(Pgk1-cre)1Lni/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• WNK lysine deficient protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:2442092
• transgene insertion 1, Peter Lonai
  http://metadb.riken.jp/db/mgi_rdf/MGI:2178049

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Wnk1<tm2.1Juha>/Wnk1<+>,Tg(Pgk1-cre)1Lni/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Wnk1<tm2.1Juha>|Wnk1<+>|Tg(Pgk1-cre)1Lni

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased urine aldosterone level
  http://purl.obolibrary.org/obo/MP_0011540

文献

http://purl.org/net/cito/citesAsAuthority

• Emmanuelle. Vidal-Petiot, et.al., WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110
  http://rdf.ncbi.nlm.nih.gov/pubmed/23940364