Jessica R. Adams, et.al., Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation., Cancer research, 2011, 71

http://rdf.ncbi.nlm.nih.gov/pubmed/21324922

Jessica R. Adams, et.al., Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation., Cancer research, 2011, 71

rdfs:label

http://www.w3.org/2000/01/rdf-schema#label

• Jessica R. Adams, et.al., Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation., Cancer research, 2011, 71

article

http://www.w3.org/2000/01/rdf-schema#seeAlso

• [Blank]
• [Blank]

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased T cell derived lymphoma incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0002024I129P2OlaHsd129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTrp53tm1BrnTrp53tm1BrnTgMMTVcreTfln0GtROSA26Sortm1Pik3caH1047REganTgMMTVcreTflnGtROSA26SorTrp53tm1Brn
• increased mammary gland tumor incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0010299I129P2OlaHsd129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcreTfln0Trp53tm1BrnTrp53GtROSA26SorTrp53tm1BrnGtROSA26Sortm1Pik3caH1047REganTrp53TgMMTVcreTfln
• no abnormal phenotype detected_Gt(ROSA)26Sor<tm2(Pik3ca)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0002169I129S6SvEvTacGtROSA26Sortm2Pik3caEganGtROSA26SorTgMMTVcreTfln0TgMMTVcreTflnGtROSA26Sortm2Pik3caEganGtROSA26Sor
• increased mammary adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0001883I129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcreTfln0GtROSA26Sortm1Pik3caH1047REganTgMMTVcreTflnGtROSA26Sor
• increased lymphoma incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0012431I129P2OlaHsd129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcreTfln0Trp53tm1BrnTrp53GtROSA26SorTrp53tm1BrnGtROSA26Sortm1Pik3caH1047REganTrp53TgMMTVcreTfln
• premature death_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcreTfln0Trp53tm1BrnTrp53GtROSA26SorTrp53tm1BrnGtROSA26Sortm1Pik3caH1047REganTrp53TgMMTVcreTfln
• increased mammary adenocarcinoma incidence_Trp53<tm1Brn>/Trp53<+>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0001883I129P2OlaHsdTrp53tm1BrnTrp53TgMMTVcreTfln0TgMMTVcreTflnTrp53Trp53tm1Brn
• increased tumor incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0002020I129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcreTfln0GtROSA26Sortm1Pik3caH1047REganTgMMTVcreTflnGtROSA26Sor
• abnormal blood vessel morphology_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001614I129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorGtROSA26Sortm1Pik3caH1047REganGtROSA26Sor
• no abnormal phenotype detected_Gt(ROSA)26Sor<tm2(Pik3ca)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)1Mam/0
  http://metadb.riken.jp/0002169I129S6SvEvTacFVBNGtROSA26Sortm2Pik3caEganGtROSA26SorTgMMTVcre1Mam0GtROSA26Sortm2Pik3caEganTgMMTVcre1MamGtROSA26Sor
• increased lymphoma incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0012431I129P2OlaHsd129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTrp53tm1BrnTrp53tm1BrnTgMMTVcreTfln0GtROSA26Sortm1Pik3caH1047REganTgMMTVcreTflnGtROSA26SorTrp53tm1Brn
• increased tumor incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)1Mam/0
  http://metadb.riken.jp/0002020I129S6SvEvTacFVBNGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcre1Mam0GtROSA26SorTgMMTVcre1MamGtROSA26Sortm1Pik3caH1047REgan
• increased mammary gland tumor incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0010299I129P2OlaHsd129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTrp53tm1BrnTrp53tm1BrnTgMMTVcreTfln0GtROSA26Sortm1Pik3caH1047REganTgMMTVcreTflnGtROSA26SorTrp53tm1Brn
• increased mammary gland tumor incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)1Mam/0
  http://metadb.riken.jp/0010299I129S6SvEvTacFVBNGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcre1Mam0GtROSA26SorTgMMTVcre1MamGtROSA26Sortm1Pik3caH1047REgan
• premature death_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0002083I129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcreTfln0GtROSA26Sortm1Pik3caH1047REganTgMMTVcreTflnGtROSA26Sor
• premature death_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTrp53tm1BrnTrp53tm1BrnTgMMTVcreTfln0GtROSA26Sortm1Pik3caH1047REganTgMMTVcreTflnGtROSA26SorTrp53tm1Brn
• increased mammary gland tumor incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0010299I129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcreTfln0GtROSA26Sortm1Pik3caH1047REganTgMMTVcreTflnGtROSA26Sor
• increased T cell derived lymphoma incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0002024I129P2OlaHsd129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcreTfln0Trp53tm1BrnTrp53GtROSA26SorTrp53tm1BrnGtROSA26Sortm1Pik3caH1047REganTrp53TgMMTVcreTfln
• premature death_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorGtROSA26Sortm1Pik3caH1047REganGtROSA26Sor
• increased mammary gland tumor incidence_Trp53<tm1Brn>/Trp53<+>,Tg(MMTV-cre)#Tfln/0
  http://metadb.riken.jp/0010299I129P2OlaHsdTrp53tm1BrnTrp53TgMMTVcreTfln0TgMMTVcreTflnTrp53Trp53tm1Brn
• increased mammary adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0,Trp53<tm1Brn>/Trp53<+>
  http://metadb.riken.jp/0001883I129P2OlaHsd129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcreTfln0Trp53tm1BrnTrp53GtROSA26SorTrp53tm1BrnGtROSA26Sortm1Pik3caH1047REganTrp53TgMMTVcreTfln
• premature death_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)1Mam/0
  http://metadb.riken.jp/0002083I129S6SvEvTacFVBNGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcre1Mam0GtROSA26SorTgMMTVcre1MamGtROSA26Sortm1Pik3caH1047REgan

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal blood vessel morphology in RBRC09421
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012510
• premature death in RBRC09421
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012509

Class

http://purl.org/net/cito/citesAsAuthority

• FVB.129S6-Gt(ROSA)26Sor<tm1(Pik3ca*E545K)Egan>
  http://metadb.riken.jp/db/rikenbrc_mouse/RBRC09422
• FVB.129S6-Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>
  http://metadb.riken.jp/db/rikenbrc_mouse/RBRC09421

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000472
• Gt(ROSA)26Sor<tm2(Pik3ca)Egan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000473

BRC マウスの系統

http://purl.org/net/cito/citesAsAuthority

• FVB.129S6-Gt(ROSA)26Sor<tm1(Pik3ca*E545K)Egan>
  http://metadb.riken.jp/db/rikenbrc_mouse/RBRC09422
• FVB.129S6-Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>
  http://metadb.riken.jp/db/rikenbrc_mouse/RBRC09421

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000472
• Gt(ROSA)26Sor<tm2(Pik3ca)Egan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000473